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- W2592486760 abstract "Hypertension is a common disorder with substantial impact on public health due to highly elevated cardiovascular risk. The mechanisms still remain unclear and treatments are not sufficient to reduce risk in majority of patients. Inflammatory mechanisms may provide an important mechanism linking hypertension and cardiovascular risk. We aim to review newly identified immune and inflammatory mechanisms of hypertension with focus on their potential therapeutic impact. In addition to the established role of the vasculature, kidneys and central nervous system in pathogenesis of hypertension, low-grade inflammation contributes to this disorder as indicated by experimental models and GWAS studies pointing to SH2B3 immune gene as top key driver of hypertension. Immune responses in hypertension are greatly driven by neoantigens generated by oxidative stress and modulated by chemokines such as RANTES, IP-10 and microRNAs including miR-21 and miR-155 with other molecules under investigation. Cells of both innate and adoptive immune system infiltrate vasculature and kidneys, affecting their function by releasing pro-inflammatory mediators and reactive oxygen species. Immune and inflammatory mechanisms of hypertension provide a link between high blood pressure and increased cardiovascular risk, and reduction of blood pressure without attention to these underlying mechanisms is not sufficient to reduce risk." @default.
- W2592486760 created "2017-03-16" @default.
- W2592486760 creator A5038811368 @default.
- W2592486760 creator A5040329167 @default.
- W2592486760 creator A5074974116 @default.
- W2592486760 creator A5078917807 @default.
- W2592486760 date "2017-03-06" @default.
- W2592486760 modified "2023-10-06" @default.
- W2592486760 title "Novel Immune Mechanisms in Hypertension and Cardiovascular Risk" @default.
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