FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2592490003> ?p ?o ?g. }

• W2592490003 endingPage "1465" @default.
• W2592490003 startingPage "1453" @default.
• W2592490003 abstract "Bipolar disorder (BD) is a progressive psychiatric disorder with more than 3% prevalence worldwide. Affected individuals experience recurrent episodes of depression and mania, disrupting normal life and increasing the risk of suicide greatly. The complexity and genetic heterogeneity of psychiatric disorders have challenged the development of animal and cellular models. We recently reported that hippocampal dentate gyrus (DG) neurons differentiated from induced pluripotent stem cell (iPSC)-derived fibroblasts of BD patients are electrophysiologically hyperexcitable. Here we used iPSCs derived from Epstein-Barr virus-immortalized B-lymphocytes to verify that the hyperexcitability of DG-like neurons is reproduced in this different cohort of patients and cells. Lymphocytes are readily available for research with a large number of banked lines with associated patient clinical description. We used whole-cell patch-clamp recordings of over 460 neurons to characterize neurons derived from control individuals and BD patients. Extensive functional analysis showed that intrinsic cell parameters are very different between the two groups of BD neurons, those derived from lithium (Li)-responsive (LR) patients and those derived from Li-non-responsive (NR) patients, which led us to partition our BD neurons into two sub-populations of cells and suggested two different subdisorders. Training a Naïve Bayes classifier with the electrophysiological features of patients whose responses to Li are known allows for accurate classification with more than 92% success rate for a new patient whose response to Li is unknown. Despite their very different functional profiles, both populations of neurons share a large, fast after-hyperpolarization (AHP). We therefore suggest that the large, fast AHP is a key feature of BD and a main contributor to the fast, sustained spiking abilities of BD neurons. Confirming our previous report with fibroblast-derived DG neurons, chronic Li treatment reduced the hyperexcitability in the lymphoblast-derived LR group but not in the NR group, strengthening the validity and utility of this new human cellular model of BD." @default.
• W2592490003 created "2017-03-16" @default.
• W2592490003 creator A5001814862 @default.
• W2592490003 creator A5002628021 @default.
• W2592490003 creator A5013106549 @default.
• W2592490003 creator A5013348661 @default.
• W2592490003 creator A5019496408 @default.
• W2592490003 creator A5021146601 @default.
• W2592490003 creator A5046759700 @default.
• W2592490003 creator A5056643939 @default.
• W2592490003 creator A5059618427 @default.
• W2592490003 creator A5069225949 @default.
• W2592490003 creator A5072968010 @default.
• W2592490003 creator A5082222907 @default.
• W2592490003 date "2017-02-28" @default.
• W2592490003 modified "2023-10-18" @default.
• W2592490003 title "Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients’ responsiveness to lithium" @default.
• W2592490003 cites W11021844 @default.
• W2592490003 cites W1520373639 @default.
• W2592490003 cites W1554979205 @default.
• W2592490003 cites W1747998245 @default.
• W2592490003 cites W1968640588 @default.
• W2592490003 cites W1968700646 @default.
• W2592490003 cites W1972039708 @default.
• W2592490003 cites W1974702488 @default.
• W2592490003 cites W1993588417 @default.
• W2592490003 cites W1996122356 @default.
• W2592490003 cites W1998003466 @default.
• W2592490003 cites W2006098113 @default.
• W2592490003 cites W2007816528 @default.
• W2592490003 cites W2021176348 @default.
• W2592490003 cites W2023456394 @default.
• W2592490003 cites W2035121417 @default.
• W2592490003 cites W2046808517 @default.
• W2592490003 cites W2049165791 @default.
• W2592490003 cites W2050917547 @default.
• W2592490003 cites W2051209170 @default.
• W2592490003 cites W2051788298 @default.
• W2592490003 cites W2056661320 @default.
• W2592490003 cites W2062963816 @default.
• W2592490003 cites W2064554173 @default.
• W2592490003 cites W2066830592 @default.
• W2592490003 cites W2075990020 @default.
• W2592490003 cites W2077592088 @default.
• W2592490003 cites W2079384709 @default.
• W2592490003 cites W2083524390 @default.
• W2592490003 cites W2086234351 @default.
• W2592490003 cites W2087955490 @default.
• W2592490003 cites W2089216562 @default.
• W2592490003 cites W2090056604 @default.
• W2592490003 cites W2097480079 @default.
• W2592490003 cites W2098378665 @default.
• W2592490003 cites W2098597355 @default.
• W2592490003 cites W2099017168 @default.
• W2592490003 cites W2102722285 @default.
• W2592490003 cites W2104559525 @default.
• W2592490003 cites W2109936356 @default.
• W2592490003 cites W2110251621 @default.
• W2592490003 cites W2114272370 @default.
• W2592490003 cites W2121408857 @default.
• W2592490003 cites W2123719127 @default.
• W2592490003 cites W2126468386 @default.
• W2592490003 cites W2127442418 @default.
• W2592490003 cites W2133752646 @default.
• W2592490003 cites W2134396686 @default.
• W2592490003 cites W2136422355 @default.
• W2592490003 cites W2136869363 @default.
• W2592490003 cites W2139372806 @default.
• W2592490003 cites W2145141773 @default.
• W2592490003 cites W2149239840 @default.
• W2592490003 cites W2156305088 @default.
• W2592490003 cites W2161282771 @default.
• W2592490003 cites W2166260758 @default.
• W2592490003 cites W2320983896 @default.
• W2592490003 cites W2468590741 @default.
• W2592490003 cites W3042079074 @default.
• W2592490003 cites W4253487572 @default.
• W2592490003 cites W63230440 @default.
• W2592490003 cites W2274666056 @default.
• W2592490003 doi "https://doi.org/10.1038/mp.2016.260" @default.
• W2592490003 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5573640" @default.
• W2592490003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28242870" @default.
• W2592490003 hasPublicationYear "2017" @default.
• W2592490003 type Work @default.
• W2592490003 sameAs 2592490003 @default.
• W2592490003 citedByCount "109" @default.
• W2592490003 countsByYear W25924900032017 @default.
• W2592490003 countsByYear W25924900032018 @default.
• W2592490003 countsByYear W25924900032019 @default.
• W2592490003 countsByYear W25924900032020 @default.
• W2592490003 countsByYear W25924900032021 @default.
• W2592490003 countsByYear W25924900032022 @default.
• W2592490003 countsByYear W25924900032023 @default.
• W2592490003 crossrefType "journal-article" @default.
• W2592490003 hasAuthorship W2592490003A5001814862 @default.
• W2592490003 hasAuthorship W2592490003A5002628021 @default.
• W2592490003 hasAuthorship W2592490003A5013106549 @default.
• W2592490003 hasAuthorship W2592490003A5013348661 @default.

• next