FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2592496066> ?p ?o ?g. }

• W2592496066 endingPage "1393" @default.
• W2592496066 startingPage "1385" @default.
• W2592496066 abstract "Acne inversa (AI)/hidradenitis suppurativa is a chronic inflammatory disease characterized by painful axillary, inguinal and perianal skin lesions with deep‐seated nodules, abscesses and fistulae. This study aimed to identify and characterize the key players in AI pathogenesis. Epidemiological and anamnestic data for patients with AI were collected, and blood and skin samples were also taken. Healthy participants and patients with psoriasis served as controls. Assessment of samples and cultures of primary cells was performed by enzyme‐linked immunosorbent assay, quantitative polymerase chain reaction on reverse transcribed mRNA, and immunohistochemistry. Of 35 mediators quantified in the blood of patients with AI, lipocalin‐2 (LCN2) appeared as one of the most significantly upregulated parameters compared with healthy participants [85·8 ± 12·2 (n = 18) vs. 41·8 ± 4·2 (n = 15); P < 0·001]. Strongly elevated LCN2 expression was present in AI lesions, with granulocytes and keratinocytes being sources of this expression. In vitro, these cells upregulated LCN2 production in response to tumour necrosis factor (TNF)‐α, and a positive relationship between systemic TNF‐α and LCN2 levels (rs = 0·55, P = 0·011; n = 20) was evident for AI. LCN2 blood levels correlated with AI disease severity (rs = 0·65, P < 0·001; n = 29), but not with disease duration, age, sex, body mass index or smoking habit. Detailed analyses revealed a link with the number of skin regions containing nodules and fistulae, but not scars. LCN2 might serve as a blood biomarker for the objective assessment of inflammatory activity in AI. We suggest a self‐amplification loop comprising TNF‐α, neutrophilic granulocytes and LCN2, which contributes to the recurrent skin neutrophil infiltration in AI, clinically evident as pus." @default.
• W2592496066 created "2017-03-16" @default.
• W2592496066 creator A5015963005 @default.
• W2592496066 creator A5018780132 @default.
• W2592496066 creator A5028262328 @default.
• W2592496066 creator A5037283048 @default.
• W2592496066 creator A5047601236 @default.
• W2592496066 creator A5049060150 @default.
• W2592496066 creator A5057872727 @default.
• W2592496066 creator A5069723448 @default.
• W2592496066 creator A5079084283 @default.
• W2592496066 creator A5089846663 @default.
• W2592496066 date "2017-09-19" @default.
• W2592496066 modified "2023-10-14" @default.
• W2592496066 title "Lipocalin‐2 is expressed by activated granulocytes and keratinocytes in affected skin and reflects disease activity in acne inversa/hidradenitis suppurativa" @default.
• W2592496066 cites W1581869568 @default.
• W2592496066 cites W1582320335 @default.
• W2592496066 cites W1590044876 @default.
• W2592496066 cites W1865135695 @default.
• W2592496066 cites W1905011311 @default.
• W2592496066 cites W1913507263 @default.
• W2592496066 cites W1914523963 @default.
• W2592496066 cites W1964392249 @default.
• W2592496066 cites W1973670195 @default.
• W2592496066 cites W2011603291 @default.
• W2592496066 cites W2016341061 @default.
• W2592496066 cites W2043806528 @default.
• W2592496066 cites W2065828171 @default.
• W2592496066 cites W2091683231 @default.
• W2592496066 cites W2103018315 @default.
• W2592496066 cites W2105079091 @default.
• W2592496066 cites W2108360478 @default.
• W2592496066 cites W2108851815 @default.
• W2592496066 cites W2112121033 @default.
• W2592496066 cites W2115514623 @default.
• W2592496066 cites W2123039495 @default.
• W2592496066 cites W2123683736 @default.
• W2592496066 cites W2138998607 @default.
• W2592496066 cites W2143973423 @default.
• W2592496066 cites W2148920499 @default.
• W2592496066 cites W2158193558 @default.
• W2592496066 cites W2175027747 @default.
• W2592496066 cites W2192166578 @default.
• W2592496066 cites W2215409508 @default.
• W2592496066 cites W2503109448 @default.
• W2592496066 cites W2521136393 @default.
• W2592496066 cites W4238251256 @default.
• W2592496066 cites W4250514769 @default.
• W2592496066 cites W85084227 @default.
• W2592496066 doi "https://doi.org/10.1111/bjd.15424" @default.
• W2592496066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28256718" @default.
• W2592496066 hasPublicationYear "2017" @default.
• W2592496066 type Work @default.
• W2592496066 sameAs 2592496066 @default.
• W2592496066 citedByCount "66" @default.
• W2592496066 countsByYear W25924960662017 @default.
• W2592496066 countsByYear W25924960662018 @default.
• W2592496066 countsByYear W25924960662019 @default.
• W2592496066 countsByYear W25924960662020 @default.
• W2592496066 countsByYear W25924960662021 @default.
• W2592496066 countsByYear W25924960662022 @default.
• W2592496066 countsByYear W25924960662023 @default.
• W2592496066 crossrefType "journal-article" @default.
• W2592496066 hasAuthorship W2592496066A5015963005 @default.
• W2592496066 hasAuthorship W2592496066A5018780132 @default.
• W2592496066 hasAuthorship W2592496066A5028262328 @default.
• W2592496066 hasAuthorship W2592496066A5037283048 @default.
• W2592496066 hasAuthorship W2592496066A5047601236 @default.
• W2592496066 hasAuthorship W2592496066A5049060150 @default.
• W2592496066 hasAuthorship W2592496066A5057872727 @default.
• W2592496066 hasAuthorship W2592496066A5069723448 @default.
• W2592496066 hasAuthorship W2592496066A5079084283 @default.
• W2592496066 hasAuthorship W2592496066A5089846663 @default.
• W2592496066 hasConcept C126322002 @default.
• W2592496066 hasConcept C142724271 @default.
• W2592496066 hasConcept C16005928 @default.
• W2592496066 hasConcept C20299238 @default.
• W2592496066 hasConcept C203014093 @default.
• W2592496066 hasConcept C2776002364 @default.
• W2592496066 hasConcept C2777357209 @default.
• W2592496066 hasConcept C2777673923 @default.
• W2592496066 hasConcept C2779134260 @default.
• W2592496066 hasConcept C2780564577 @default.
• W2592496066 hasConcept C2780942790 @default.
• W2592496066 hasConcept C2781197716 @default.
• W2592496066 hasConcept C55493867 @default.
• W2592496066 hasConcept C71924100 @default.
• W2592496066 hasConcept C86803240 @default.
• W2592496066 hasConcept C90924648 @default.
• W2592496066 hasConceptScore W2592496066C126322002 @default.
• W2592496066 hasConceptScore W2592496066C142724271 @default.
• W2592496066 hasConceptScore W2592496066C16005928 @default.
• W2592496066 hasConceptScore W2592496066C20299238 @default.
• W2592496066 hasConceptScore W2592496066C203014093 @default.
• W2592496066 hasConceptScore W2592496066C2776002364 @default.
• W2592496066 hasConceptScore W2592496066C2777357209 @default.
• W2592496066 hasConceptScore W2592496066C2777673923 @default.
• W2592496066 hasConceptScore W2592496066C2779134260 @default.

• next