FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2592521807> ?p ?o ?g. }

• W2592521807 abstract "In response to microenvironmental cues, macrophages undergo a profound phenotypic transformation acquiring distinct activation phenotypes ranging from pro-inflammatory (M1) to anti-inflammatory (M2). To study how activation phenotype influences phagocytosis and production of reactive oxygen species (ROS) mediated by receptors for IgG antibodies (Fcγ receptors) and by CD13, human monocyte-derived macrophages were polarized to distinct phenotypes using IFN-γ (Mϕ-IFN-γ), IL-4 (Mϕ-IL-4), or IL-10 (Mϕ-IL-10). Phenotypically, Mϕ-IFN-γ were characterized as CD14+CD80+CD86+ cells, Mϕ-IL-4 as CD209highCD206+CD11b+CD14low, and Mϕ-IL-10 as CD16+CD163+ cells. Compared to non-polarized macrophages, FcγRI expression increased in Mϕ-IFN-γ and Mϕ-IL-10 and FcγRIII expression increased in Mϕ-IL-10. None of the polarizing cytokines modified FcγRII or CD13 expression. Functionally, we found that cytokine-mediated activation significantly and distinctively affected FcγR- and CD13-mediated phagocytosis and ROS generation. Compared to non-polarized macrophages, FcγRI-, FcγRII-, and CD13-mediated phagocytosis was significantly increased in Mϕ-IL-10 and decreased in Mϕ-IFN-γ, although both cytokines significantly upregulated FcγRI expression. IL-10 also increased phagocytosis of Escherichia coli, showing that the effect of IL-10 on macrophage phagocytosis is not specific for a particular receptor. Interestingly, Mϕ-IL-4, which showed poor FcγR- and CD13-mediated phagocytosis, showed very high phagocytosis of E. coli and zymosan. Coupled with phagocytosis, macrophages produce ROS that contribute to microbial killing. As expected, Mϕ-IFN-γ showed significant production of ROS after FcγRI-, FcγRII-, or CD13-mediated phagocytosis. Unexpectedly, we found that Mϕ-IL-10 can also produce ROS after simultaneous stimulation through several phagocytic receptors, as coaggregation of FcγRI/FcγRII/CD13 induced a belated but significant ROS production. Together, these results demonstrate that activation of macrophages by each cytokine distinctly modulates expression of phagocytic receptors, FcγR- and CD13-mediated phagocytosis, and ROS production." @default.
• W2592521807 created "2017-03-16" @default.
• W2592521807 creator A5056111143 @default.
• W2592521807 creator A5083038211 @default.
• W2592521807 date "2017-03-27" @default.
• W2592521807 modified "2023-10-10" @default.
• W2592521807 title "Macrophage Polarization Modulates FcγR- and CD13-Mediated Phagocytosis and Reactive Oxygen Species Production, Independently of Receptor Membrane Expression" @default.
• W2592521807 cites W1481966022 @default.
• W2592521807 cites W1496174628 @default.
• W2592521807 cites W1554952565 @default.
• W2592521807 cites W156684494 @default.
• W2592521807 cites W1923917571 @default.
• W2592521807 cites W1925976975 @default.
• W2592521807 cites W1954215697 @default.
• W2592521807 cites W1955288634 @default.
• W2592521807 cites W1962869168 @default.
• W2592521807 cites W1968619160 @default.
• W2592521807 cites W1981670631 @default.
• W2592521807 cites W1983220630 @default.
• W2592521807 cites W1983342808 @default.
• W2592521807 cites W1985929369 @default.
• W2592521807 cites W1986736465 @default.
• W2592521807 cites W1990523202 @default.
• W2592521807 cites W1994749115 @default.
• W2592521807 cites W2004727400 @default.
• W2592521807 cites W2005226926 @default.
• W2592521807 cites W2012416768 @default.
• W2592521807 cites W2016293419 @default.
• W2592521807 cites W2025760628 @default.
• W2592521807 cites W2028101883 @default.
• W2592521807 cites W2031908200 @default.
• W2592521807 cites W2035817205 @default.
• W2592521807 cites W2047771008 @default.
• W2592521807 cites W2060766291 @default.
• W2592521807 cites W2061123122 @default.
• W2592521807 cites W2067616322 @default.
• W2592521807 cites W2070855360 @default.
• W2592521807 cites W2075901113 @default.
• W2592521807 cites W2081810806 @default.
• W2592521807 cites W2088616891 @default.
• W2592521807 cites W2089573250 @default.
• W2592521807 cites W2093705034 @default.
• W2592521807 cites W2102970290 @default.
• W2592521807 cites W2107551122 @default.
• W2592521807 cites W2109593516 @default.
• W2592521807 cites W2115993724 @default.
• W2592521807 cites W2119194984 @default.
• W2592521807 cites W2119305519 @default.
• W2592521807 cites W2121843507 @default.
• W2592521807 cites W2127123481 @default.
• W2592521807 cites W2129142879 @default.
• W2592521807 cites W2133211829 @default.
• W2592521807 cites W2140380746 @default.
• W2592521807 cites W2147075618 @default.
• W2592521807 cites W2147105664 @default.
• W2592521807 cites W2156539075 @default.
• W2592521807 cites W2159560463 @default.
• W2592521807 cites W2161074777 @default.
• W2592521807 cites W2163175900 @default.
• W2592521807 cites W2165346899 @default.
• W2592521807 cites W2168403919 @default.
• W2592521807 cites W2170375725 @default.
• W2592521807 cites W2394804415 @default.
• W2592521807 cites W2606865761 @default.
• W2592521807 doi "https://doi.org/10.3389/fimmu.2017.00303" @default.
• W2592521807 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5366847" @default.
• W2592521807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28396660" @default.
• W2592521807 hasPublicationYear "2017" @default.
• W2592521807 type Work @default.
• W2592521807 sameAs 2592521807 @default.
• W2592521807 citedByCount "52" @default.
• W2592521807 countsByYear W25925218072017 @default.
• W2592521807 countsByYear W25925218072018 @default.
• W2592521807 countsByYear W25925218072019 @default.
• W2592521807 countsByYear W25925218072020 @default.
• W2592521807 countsByYear W25925218072021 @default.
• W2592521807 countsByYear W25925218072022 @default.
• W2592521807 countsByYear W25925218072023 @default.
• W2592521807 crossrefType "journal-article" @default.
• W2592521807 hasAuthorship W2592521807A5056111143 @default.
• W2592521807 hasAuthorship W2592521807A5083038211 @default.
• W2592521807 hasBestOaLocation W25925218071 @default.
• W2592521807 hasConcept C114684123 @default.
• W2592521807 hasConcept C154317977 @default.
• W2592521807 hasConcept C160448771 @default.
• W2592521807 hasConcept C167672396 @default.
• W2592521807 hasConcept C170493617 @default.
• W2592521807 hasConcept C171779818 @default.
• W2592521807 hasConcept C187316574 @default.
• W2592521807 hasConcept C202751555 @default.
• W2592521807 hasConcept C203014093 @default.
• W2592521807 hasConcept C2775858924 @default.
• W2592521807 hasConcept C2776070231 @default.
• W2592521807 hasConcept C2776090121 @default.
• W2592521807 hasConcept C2778297628 @default.
• W2592521807 hasConcept C2778513237 @default.
• W2592521807 hasConcept C2778690821 @default.
• W2592521807 hasConcept C2778870864 @default.
• W2592521807 hasConcept C2779244956 @default.
• W2592521807 hasConcept C2779931124 @default.

• next