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- W2592525136 abstract "Aberrant PRC2 activity produces gene repressive epigenetic marks in multiple diseases and led to identification of Ezh2 as a drug target. Recent studies have shown that the epigenetic reader protein EED, associated with Ezh2 in PRC2, has an additional function to stimulate the PRC2 activity after binding to H3K27me3. Optimizing a compound known to block the H3K27me3 site in EED discovered by in-house screening, Novartis scientists have now produced a compound that shows durable tumor regression in a lymphoma xenograft model." @default.
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- W2592525136 date "2017-03-03" @default.
- W2592525136 modified "2023-10-16" @default.
- W2592525136 title "Allosteric Inactivation of Polycomb Repressive Complex 2 (PRC2) by Inhibiting Its Adapter Protein: Embryonic Ectodomain Development (EED)" @default.
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- W2592525136 doi "https://doi.org/10.1021/acs.jmedchem.7b00287" @default.
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