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- W2592627283 abstract "Abstract The microbiome is a regulator of host immunity, metabolism, neurodevelopment, and behavior. During early life, bacterial communities within maternal gut and vaginal compartments can have an impact on directing these processes. Maternal stress experience during pregnancy may impact offspring development by altering the temporal and spatial dynamics of the maternal microbiome during pregnancy. To examine the hypothesis that maternal stress disrupts gut and vaginal microbial dynamics during critical prenatal and postnatal windows, we used high-resolution 16S rRNA marker gene sequencing to examine outcomes in our mouse model of early prenatal stress. Consistent with predictions, maternal fecal communities shift across pregnancy, a process that is disrupted by stress. Vaginal bacterial community structure and composition exhibit lasting disruption following stress exposure. Comparison of maternal and offspring microbiota revealed that similarities in bacterial community composition was predicted by a complex interaction between maternal body niche and offspring age and sex. Importantly, early prenatal stress influenced offspring bacterial community assembly in a temporal and sex-specific manner. Taken together, our results demonstrate that early prenatal stress may influence offspring development through converging modifications to gut microbial composition during pregnancy and transmission of dysbiotic vaginal microbiome at birth." @default.
- W2592627283 created "2017-03-16" @default.
- W2592627283 creator A5048992881 @default.
- W2592627283 creator A5051876711 @default.
- W2592627283 creator A5066980572 @default.
- W2592627283 creator A5077699942 @default.
- W2592627283 creator A5090415813 @default.
- W2592627283 date "2017-03-07" @default.
- W2592627283 modified "2023-10-11" @default.
- W2592627283 title "Stress during pregnancy alters temporal and spatial dynamics of the maternal and offspring microbiome in a sex-specific manner" @default.
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