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- W2592654559 abstract "The asymmetric bioreduction of several saturated N-heterocyclic ketones is demonstrated in a stereo-complementary fashion using the ketoreductases READH and ChKRED20 for the production of (S)- and (R)-alcohols, respectively. The reaction accepts substrates with a five-, six- or seven-membered ring, and exhibits excellent stereoselectivity when using 2-propanol as both the ultimate reducing agent and cosolvent, achieve >99% ee in the majority of cases for both enantiomers." @default.
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- W2592654559 date "2017-05-01" @default.
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- W2592654559 title "Stereo-complementary bioreduction of saturated N -heterocyclic ketones" @default.
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- W2592654559 doi "https://doi.org/10.1016/j.procbio.2017.03.002" @default.
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