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- W2592671116 abstract "Objective The intravenous formulation of lacosamide (LCM) and its good overall tolerability and safety favor the use in status epilepticus (SE). The aim of this systematic review was to identify and evaluate studies reporting on the use of LCM in SE. Methods We performed a systematic literature search of electronic databases using a combined search strategy from 2008 until October 2016. Using a standardized assessment form, information on the study design, methodologic framework, data sources, efficacy, and adverse events attributed to LCM were extracted from each publication and systematically reported. Results In total, 522 SE episodes (51.7% female) in 486 adults and 36 children and adolescents were evaluated with an overall LCM efficacy of 57%. Efficacy was comparable between use in nonconvulsive (57%; 82/145) and generalized-convulsive (61%; 30/49; p = 0.68) SE, whereas overall success rate was better in focal motor SE (92%; 34/39, p = 0.013; p < 0.001). The efficacy with later positioning of LCM decreased from 100% to 20%. The main adverse events during treatment of SE are dizziness, abnormal vision, diplopia, and ataxia. Overall, lacosamide is well tolerated and has no clinically relevant drug–drug interactions. Significance The available data regarding the use of LCM in SE are promising, with a success rate of 57%. The strength of LCM is the lack of interaction potential and the option for intravenous use in emergency situations requiring rapid uptitration." @default.
- W2592671116 created "2017-03-16" @default.
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- W2592671116 date "2017-03-11" @default.
- W2592671116 modified "2023-10-15" @default.
- W2592671116 title "Lacosamide in status epilepticus: Systematic review of current evidence" @default.
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- W2592671116 doi "https://doi.org/10.1111/epi.13716" @default.
- W2592671116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28295226" @default.
- W2592671116 hasPublicationYear "2017" @default.
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