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- W2592687264 abstract "Diagnosis of implant-related (periprosthetic joint) infections poses a major challenge to infection disease physicians and orthopaedic surgeons. Conventional diagnostic tests continue to suffer from issues of accuracy and feasibility. Biomarkers are used throughout medicine for diagnostic and prognostic purposes, as they are able to objectively determine the presence of a disease or a biological state. There is increasing evidence to support the measurement of specific biomarkers in serum and/or synovial fluid of patients with suspected periprosthetic joint infections. Promising serum biomarkers include interleukin (IL)-4, IL-6, tumour necrosis factor (TNF)-α, procalcitonin, soluble intercellular adhesion molecule 1 (sICAM-1), and D-dimer. In addition to c-reactive protein and leucocyte esterase, promising biomarkers that can be measured in synovial fluid include antimicrobial proteins such as human β-defensin (HBD)-2 and human β-defensin (HBD)-3, and cathelicidin LL-37, as well as several interleukins such as IL-1β, IL-6, IL-8, IL-17, TNF- α, interferon-δ, and vascular endothelial growth factor." @default.
- W2592687264 created "2017-03-16" @default.
- W2592687264 creator A5009567309 @default.
- W2592687264 creator A5030106343 @default.
- W2592687264 creator A5038532275 @default.
- W2592687264 date "2017-01-01" @default.
- W2592687264 modified "2023-09-24" @default.
- W2592687264 title "The Role of Biomarkers for the Diagnosis of Implant-Related Infections in Orthopaedics and Trauma" @default.
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- W2592687264 doi "https://doi.org/10.1007/5584_2017_11" @default.
- W2592687264 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28243953" @default.
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