Matches in SemOpenAlex for { <https://semopenalex.org/work/W2592715682> ?p ?o ?g. }
- W2592715682 endingPage "950" @default.
- W2592715682 startingPage "941" @default.
- W2592715682 abstract "Abstract The lipases/acyltransferases homologous to CpLIP2 of Candida parapsilosis efficiently catalyze acyltransfer reactions in lipid/water media with high water activity ( a W >0.9). Two new enzymes of this family, CduLAc from Candida dubliniensis and CalLAc8 from Candida albicans, were characterized. Despite 82 % sequence identity, the two enzymes have significant differences in their catalytic behaviors. In order to understand the roles played by the different subdomains of these proteins (main core, cap and C‐terminal flap), chimeric enzymes were designed by rational exchange of cap and C‐terminal flap, between CduLAc and CalLAc8. The results show that the cap region plays a significant role in substrate specificity; the main core was found to be the most important part of the protein for acyltransfer ability. Similar exchanges were made with CAL‐A from Candida antarctica , but only the C‐terminal exchange was successful. Yet, the role of this domain was not clearly elucidated, other than that it is essential for activity." @default.
- W2592715682 created "2017-03-16" @default.
- W2592715682 creator A5016061297 @default.
- W2592715682 creator A5039989460 @default.
- W2592715682 creator A5077432605 @default.
- W2592715682 date "2017-05-03" @default.
- W2592715682 modified "2023-10-01" @default.
- W2592715682 title "Revealing the Roles of Subdomains in the Catalytic Behavior of Lipases/Acyltransferases Homologous to CpLIP2 through Rational Design of Chimeric Enzymes" @default.
- W2592715682 cites W1963501705 @default.
- W2592715682 cites W1966376706 @default.
- W2592715682 cites W1967261186 @default.
- W2592715682 cites W1976883040 @default.
- W2592715682 cites W1980374511 @default.
- W2592715682 cites W1986914760 @default.
- W2592715682 cites W1990805555 @default.
- W2592715682 cites W1991559170 @default.
- W2592715682 cites W2008841836 @default.
- W2592715682 cites W2010986041 @default.
- W2592715682 cites W2025212708 @default.
- W2592715682 cites W2046703733 @default.
- W2592715682 cites W2048069826 @default.
- W2592715682 cites W2048749320 @default.
- W2592715682 cites W2053225448 @default.
- W2592715682 cites W2056206495 @default.
- W2592715682 cites W2062317058 @default.
- W2592715682 cites W2062934046 @default.
- W2592715682 cites W2065283382 @default.
- W2592715682 cites W2067819039 @default.
- W2592715682 cites W2075894555 @default.
- W2592715682 cites W2077776336 @default.
- W2592715682 cites W2079626310 @default.
- W2592715682 cites W2095417541 @default.
- W2592715682 cites W2099943177 @default.
- W2592715682 cites W2110862292 @default.
- W2592715682 cites W2114520383 @default.
- W2592715682 cites W2116459264 @default.
- W2592715682 cites W2128536420 @default.
- W2592715682 cites W2132629607 @default.
- W2592715682 cites W2134967712 @default.
- W2592715682 cites W2137015675 @default.
- W2592715682 cites W2151430938 @default.
- W2592715682 cites W2152961200 @default.
- W2592715682 cites W2169648271 @default.
- W2592715682 cites W2181160810 @default.
- W2592715682 cites W2329084134 @default.
- W2592715682 cites W2423918959 @default.
- W2592715682 cites W2429538176 @default.
- W2592715682 cites W4293247451 @default.
- W2592715682 cites W770649204 @default.
- W2592715682 doi "https://doi.org/10.1002/cbic.201600672" @default.
- W2592715682 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28258600" @default.
- W2592715682 hasPublicationYear "2017" @default.
- W2592715682 type Work @default.
- W2592715682 sameAs 2592715682 @default.
- W2592715682 citedByCount "13" @default.
- W2592715682 countsByYear W25927156822017 @default.
- W2592715682 countsByYear W25927156822018 @default.
- W2592715682 countsByYear W25927156822019 @default.
- W2592715682 countsByYear W25927156822020 @default.
- W2592715682 countsByYear W25927156822021 @default.
- W2592715682 countsByYear W25927156822023 @default.
- W2592715682 crossrefType "journal-article" @default.
- W2592715682 hasAuthorship W2592715682A5016061297 @default.
- W2592715682 hasAuthorship W2592715682A5039989460 @default.
- W2592715682 hasAuthorship W2592715682A5077432605 @default.
- W2592715682 hasConcept C147816474 @default.
- W2592715682 hasConcept C181199279 @default.
- W2592715682 hasConcept C185592680 @default.
- W2592715682 hasConcept C2779443200 @default.
- W2592715682 hasConcept C2779542420 @default.
- W2592715682 hasConcept C2779697368 @default.
- W2592715682 hasConcept C2780917455 @default.
- W2592715682 hasConcept C2910079589 @default.
- W2592715682 hasConcept C53105671 @default.
- W2592715682 hasConcept C54355233 @default.
- W2592715682 hasConcept C553450214 @default.
- W2592715682 hasConcept C55493867 @default.
- W2592715682 hasConcept C71240020 @default.
- W2592715682 hasConcept C86803240 @default.
- W2592715682 hasConceptScore W2592715682C147816474 @default.
- W2592715682 hasConceptScore W2592715682C181199279 @default.
- W2592715682 hasConceptScore W2592715682C185592680 @default.
- W2592715682 hasConceptScore W2592715682C2779443200 @default.
- W2592715682 hasConceptScore W2592715682C2779542420 @default.
- W2592715682 hasConceptScore W2592715682C2779697368 @default.
- W2592715682 hasConceptScore W2592715682C2780917455 @default.
- W2592715682 hasConceptScore W2592715682C2910079589 @default.
- W2592715682 hasConceptScore W2592715682C53105671 @default.
- W2592715682 hasConceptScore W2592715682C54355233 @default.
- W2592715682 hasConceptScore W2592715682C553450214 @default.
- W2592715682 hasConceptScore W2592715682C55493867 @default.
- W2592715682 hasConceptScore W2592715682C71240020 @default.
- W2592715682 hasConceptScore W2592715682C86803240 @default.
- W2592715682 hasFunder F4320324952 @default.
- W2592715682 hasIssue "10" @default.
- W2592715682 hasLocation W25927156821 @default.
- W2592715682 hasLocation W25927156822 @default.
- W2592715682 hasLocation W25927156823 @default.