FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2592826666> ?p ?o ?g. }

• W2592826666 endingPage "425" @default.
• W2592826666 startingPage "416" @default.
• W2592826666 abstract "Healing of an anal sphincter defect at a time distant from injury is a challenge.We aimed to investigate whether re-establishing stem cell homing at the site of an anal sphincter defect when cytokine expression has declined using a plasmid engineered to express stromal derived factor 1 with or without mesenchymal stem cells can improve anatomic and functional outcome.This was a randomized animal study.Thirty-two female age- and weight-matched Sprague Dawley rats underwent 50% excision of the anal sphincter complex. Three weeks after injury, 4 interventions were randomly allocated (n = 8), including no intervention, 100-μg plasmid, plasmid and 800,000 cells, and plasmid with a gelatin scaffold mixed with cells.The differences in anal sphincter resting pressures just before and 4 weeks after intervention were used for functional analysis. Histology was analyzed using Masson staining. One-way ANOVA followed by the Tukey post hoc test was used for pressure and histological analysis.All 3 of the intervention groups had a significantly greater change in resting pressure (plasmid p = 0.009; plasmid + cells p = 0.047; plasmid + cells in scaffold p = 0.009) compared with the control group. The plasmid-with-cells group showed increased organization of muscle architecture and increased muscle percentage, whereas the control group showed disorganized architecture at the site of the defect. Histological quantification revealed significantly more muscle at the site of defect in the plasmid-plus-cells group compared with the control group, which had the least muscle. Quantification of connective tissue revealed significantly less fibrosis at the site of defect in the plasmid and plasmid-plus-cells groups compared with the control group.Midterm evaluation and muscle morphology were not defined.At this midterm follow-up, local delivery of a stromal derived factor 1 plasmid with or without local mesenchymal stem cells enhanced anal sphincter muscle regeneration long after an anal sphincter injury, thereby improving functional outcome. See Video Abstract at http://links.lww.com/DCR/A324." @default.
• W2592826666 created "2017-03-16" @default.
• W2592826666 creator A5014701473 @default.
• W2592826666 creator A5017579123 @default.
• W2592826666 creator A5024060592 @default.
• W2592826666 creator A5035254763 @default.
• W2592826666 creator A5036249177 @default.
• W2592826666 creator A5083363145 @default.
• W2592826666 date "2017-04-01" @default.
• W2592826666 modified "2023-09-26" @default.
• W2592826666 title "Regenerating the Anal Sphincter: Cytokines, Stem Cells, or Both?" @default.
• W2592826666 cites W1485698350 @default.
• W2592826666 cites W1979644919 @default.
• W2592826666 cites W1988821576 @default.
• W2592826666 cites W1989635647 @default.
• W2592826666 cites W1994812709 @default.
• W2592826666 cites W1996791303 @default.
• W2592826666 cites W2005975965 @default.
• W2592826666 cites W2009566779 @default.
• W2592826666 cites W2010472544 @default.
• W2592826666 cites W2011842631 @default.
• W2592826666 cites W2016123783 @default.
• W2592826666 cites W2020020716 @default.
• W2592826666 cites W20228888 @default.
• W2592826666 cites W2031331609 @default.
• W2592826666 cites W2031832687 @default.
• W2592826666 cites W2033835998 @default.
• W2592826666 cites W2038437457 @default.
• W2592826666 cites W2039551908 @default.
• W2592826666 cites W2048147667 @default.
• W2592826666 cites W2048835392 @default.
• W2592826666 cites W2052629224 @default.
• W2592826666 cites W2053542782 @default.
• W2592826666 cites W2053803023 @default.
• W2592826666 cites W2063250637 @default.
• W2592826666 cites W2069143361 @default.
• W2592826666 cites W2069694060 @default.
• W2592826666 cites W2091436580 @default.
• W2592826666 cites W2093651836 @default.
• W2592826666 cites W2099840106 @default.
• W2592826666 cites W2128352726 @default.
• W2592826666 cites W2131461932 @default.
• W2592826666 cites W2140580342 @default.
• W2592826666 cites W2141837666 @default.
• W2592826666 cites W2143811824 @default.
• W2592826666 cites W2158090284 @default.
• W2592826666 cites W2163109226 @default.
• W2592826666 cites W2168795803 @default.
• W2592826666 cites W2169522770 @default.
• W2592826666 cites W2169584423 @default.
• W2592826666 cites W2236106932 @default.
• W2592826666 cites W2313775336 @default.
• W2592826666 cites W2318202865 @default.
• W2592826666 cites W2324418491 @default.
• W2592826666 cites W2338206191 @default.
• W2592826666 doi "https://doi.org/10.1097/dcr.0000000000000783" @default.
• W2592826666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28267010" @default.
• W2592826666 hasPublicationYear "2017" @default.
• W2592826666 type Work @default.
• W2592826666 sameAs 2592826666 @default.
• W2592826666 citedByCount "15" @default.
• W2592826666 countsByYear W25928266662017 @default.
• W2592826666 countsByYear W25928266662018 @default.
• W2592826666 countsByYear W25928266662019 @default.
• W2592826666 countsByYear W25928266662020 @default.
• W2592826666 countsByYear W25928266662021 @default.
• W2592826666 countsByYear W25928266662022 @default.
• W2592826666 countsByYear W25928266662023 @default.
• W2592826666 crossrefType "journal-article" @default.
• W2592826666 hasAuthorship W2592826666A5014701473 @default.
• W2592826666 hasAuthorship W2592826666A5017579123 @default.
• W2592826666 hasAuthorship W2592826666A5024060592 @default.
• W2592826666 hasAuthorship W2592826666A5035254763 @default.
• W2592826666 hasAuthorship W2592826666A5036249177 @default.
• W2592826666 hasAuthorship W2592826666A5083363145 @default.
• W2592826666 hasConcept C126322002 @default.
• W2592826666 hasConcept C126894567 @default.
• W2592826666 hasConcept C141071460 @default.
• W2592826666 hasConcept C142724271 @default.
• W2592826666 hasConcept C16685009 @default.
• W2592826666 hasConcept C16930146 @default.
• W2592826666 hasConcept C198826908 @default.
• W2592826666 hasConcept C22744801 @default.
• W2592826666 hasConcept C2777399655 @default.
• W2592826666 hasConcept C2778690821 @default.
• W2592826666 hasConcept C2780035688 @default.
• W2592826666 hasConcept C2780371428 @default.
• W2592826666 hasConcept C2780877482 @default.
• W2592826666 hasConcept C2781074409 @default.
• W2592826666 hasConcept C28328180 @default.
• W2592826666 hasConcept C54355233 @default.
• W2592826666 hasConcept C552990157 @default.
• W2592826666 hasConcept C57742111 @default.
• W2592826666 hasConcept C71924100 @default.
• W2592826666 hasConcept C86803240 @default.
• W2592826666 hasConcept C95444343 @default.
• W2592826666 hasConceptScore W2592826666C126322002 @default.
• W2592826666 hasConceptScore W2592826666C126894567 @default.

• next