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• W2592833612 startingPage "4778" @default.
• W2592833612 abstract "Metallohydrolases are a vast family of enzymes that play crucial roles in numerous metabolic pathways. Several members have emerged as targets for chemotherapeutics. Knowledge about their reaction mechanisms and associated transition states greatly aids the design of potent and highly specific drug leads. By using a high-resolution crystal structure, we have probed the trajectory of the reaction catalyzed by purple acid phosphatase, an enzyme essential for the integrity of bone structure. In particular, the transition state is visualized, thus providing detailed structural information that may be exploited in the design of specific inhibitors for the development of new anti-osteoporotic chemotherapeutics." @default.
• W2592833612 created "2017-03-16" @default.
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• W2592833612 date "2017-03-23" @default.
• W2592833612 modified "2023-10-11" @default.
• W2592833612 title "Visualization of the Reaction Trajectory and Transition State in a Hydrolytic Reaction Catalyzed by a Metalloenzyme" @default.
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• W2592833612 doi "https://doi.org/10.1002/chem.201700866" @default.
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