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• W2592875302 abstract "Background: Low adherence to antihypertensive medication is an important barrier to achieving blood pressure control. Few data are available for medication adherence in adults with chronic kidney disease (CKD). Study Design: Cross-sectional. Setting & Participants: 3,936 and 9,129 participants with and without CKD using antihypertensive medication in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) Study, respectively. CKD was defined as albuminuria with albumin excretion 30 mg/g or estimated glomerular filtration rate 60 mL/min/1.73 m 2 . Outcomes: Medication adherence and uncontrolled hypertension. Measurements: Medication adherence was assessed using a validated 4-item scale. Blood pressure was measured 2 times by trained staff. Results: In REGARDS participants with and without CKD, 1,426 (36.2%) and 2,421 (26.5%) had uncontrolled hypertension with blood pressure 140/90 mm Hg, and 2,656 (67.5%) and 5,627 (61.6%), 130/80 mm Hg. Also, 27.7% of those with CKD and 27.9% of those without CKD responded “yes” to ever forgetting to take their medication and 4.4% and 4.2%, respectively, responded yes to being careless about taking their medication. Also, 5.7% and 5.3% responded yes to missing taking medication when they felt better, and 4.2% and 3.6%, to missing it when they felt sick. Overall, 23.3% and 23.7% of participants with and without CKD responded yes to 1 adherence question, whereas 7.7% and 7.2%, respectively, responded yes to 2 or more adherence questions. In those with CKD, the multivariable adjusted ORs for uncontrolled hypertension (blood pressure 140/90 mm Hg) for individuals answering yes to 1 and 2 or more versus 0 adherence questions were 1.26 (95% CI, 1.05-1.51) and 1.49 (95% CI, 1.12-1.98), respectively. Analogous ORs for systolic/diastolic blood pressure 130/80 mm Hg were 1.06 (95% CI, 0.78-1.45) and 1.20 (95% CI, 0.88-1.64). Limitations: Pharmacy fill data were not available. Conclusions: Individuals with CKD had similarly poor medication-taking behaviors as those without CKD. Am J Kidney Dis 56:447-457. ©2010 by the National Kidney Foundation, Inc." @default.
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• W2592875302 date "2010-01-01" @default.
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• W2592875302 title "ORIGINAL INVESTIGATIONS Pathogenesis and Treatment of Kidney Disease Low Medication Adherence and Hypertension Control Among Adults With CKD: Data From the REGARDS (Reasons for Geographic and Racial Differences in Stroke) Study" @default.
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