FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2592877286> ?p ?o ?g. }

• W2592877286 endingPage "1097" @default.
• W2592877286 startingPage "1092" @default.
• W2592877286 abstract "In Western countries emergence of human immunodeficiency virus (HIV) drug resistance has tremendously decreased, and transmission of drug resistance has merely stabilized in recent years. However, in many endemic settings with limited resources rates of emerging and transmitted drug resistance are not regularly assessed. We performed a survey including all HIV-infected individuals who received resistance testing in 2010–2015 in Aruba, a highly endemic HIV area in the Caribbean. Transmitted HIV drug resistance was determined using World Health Organization (WHO) criteria. Transmission dynamics were investigated using phylogenetic analyses. In a subset, baseline samples were re-analyzed using next generation sequencing (NGS). Baseline resistance testing was performed in 104 newly diagnosed untreated individuals (54% of all newly diagnosed individuals in 2010–2015): 86% were men, 39% were foreign-born, and 22% had AIDS at diagnosis. And 33% (95% CI: 24–42%) was infected with a drug-resistant HIV variant. The prevalence of resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs) reached 45% (95% CI: 27–64%) in 2015, all based on the prevalence of mutation K103N. NGS did not demonstrate additional minority K103N-variants compared to routine resistance testing. K103N-harboring strains were introduced into the therapy-unexposed population via at least 6 independent transmissions epidemiologically linked to the surrounding countries. Virological failure of the WHO-recommended first-line NNRTI-based regimen was higher in the presence of K103N. The prevalence of resistant HIV in Aruba has increased to alarming levels, compromising the WHO-recommended first-line regimen. As adequate surveillance as advocated by the WHO is limited, the Caribbean region could face an unidentified rise of NNRTI-resistant HIV." @default.
• W2592877286 created "2017-03-16" @default.
• W2592877286 creator A5002497082 @default.
• W2592877286 creator A5011622563 @default.
• W2592877286 creator A5017678982 @default.
• W2592877286 creator A5021529268 @default.
• W2592877286 creator A5022797919 @default.
• W2592877286 creator A5036284878 @default.
• W2592877286 creator A5051373841 @default.
• W2592877286 creator A5058930906 @default.
• W2592877286 creator A5062554627 @default.
• W2592877286 creator A5088158785 @default.
• W2592877286 creator A5089412898 @default.
• W2592877286 date "2017-03-09" @default.
• W2592877286 modified "2023-10-10" @default.
• W2592877286 title "High Rates of Transmission of Drug-resistant HIV in Aruba Resulting in Reduced Susceptibility to the WHO Recommended First-line Regimen in Nearly Half of Newly Diagnosed HIV-infected Patients" @default.
• W2592877286 cites W1969028669 @default.
• W2592877286 cites W1973294517 @default.
• W2592877286 cites W1974659005 @default.
• W2592877286 cites W1988013686 @default.
• W2592877286 cites W1989128673 @default.
• W2592877286 cites W2003554023 @default.
• W2592877286 cites W2012156864 @default.
• W2592877286 cites W2016976457 @default.
• W2592877286 cites W2041424522 @default.
• W2592877286 cites W2049607302 @default.
• W2592877286 cites W2085548662 @default.
• W2592877286 cites W2105329815 @default.
• W2592877286 cites W2109046728 @default.
• W2592877286 cites W2115919618 @default.
• W2592877286 cites W2116049022 @default.
• W2592877286 cites W2119284380 @default.
• W2592877286 cites W2131901040 @default.
• W2592877286 cites W2144882072 @default.
• W2592877286 cites W2150215096 @default.
• W2592877286 cites W2152505869 @default.
• W2592877286 cites W2160378127 @default.
• W2592877286 cites W2162598081 @default.
• W2592877286 cites W2163900810 @default.
• W2592877286 cites W2205249602 @default.
• W2592877286 cites W2316735532 @default.
• W2592877286 cites W2466714343 @default.
• W2592877286 cites W2625924212 @default.
• W2592877286 cites W4297914773 @default.
• W2592877286 doi "https://doi.org/10.1093/cid/cix056" @default.
• W2592877286 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5848377" @default.
• W2592877286 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28329390" @default.
• W2592877286 hasPublicationYear "2017" @default.
• W2592877286 type Work @default.
• W2592877286 sameAs 2592877286 @default.
• W2592877286 citedByCount "10" @default.
• W2592877286 countsByYear W25928772862018 @default.
• W2592877286 countsByYear W25928772862019 @default.
• W2592877286 countsByYear W25928772862020 @default.
• W2592877286 countsByYear W25928772862021 @default.
• W2592877286 countsByYear W25928772862022 @default.
• W2592877286 countsByYear W25928772862023 @default.
• W2592877286 crossrefType "journal-article" @default.
• W2592877286 hasAuthorship W2592877286A5002497082 @default.
• W2592877286 hasAuthorship W2592877286A5011622563 @default.
• W2592877286 hasAuthorship W2592877286A5017678982 @default.
• W2592877286 hasAuthorship W2592877286A5021529268 @default.
• W2592877286 hasAuthorship W2592877286A5022797919 @default.
• W2592877286 hasAuthorship W2592877286A5036284878 @default.
• W2592877286 hasAuthorship W2592877286A5051373841 @default.
• W2592877286 hasAuthorship W2592877286A5058930906 @default.
• W2592877286 hasAuthorship W2592877286A5062554627 @default.
• W2592877286 hasAuthorship W2592877286A5088158785 @default.
• W2592877286 hasAuthorship W2592877286A5089412898 @default.
• W2592877286 hasBestOaLocation W25928772861 @default.
• W2592877286 hasConcept C104317684 @default.
• W2592877286 hasConcept C114851261 @default.
• W2592877286 hasConcept C119599485 @default.
• W2592877286 hasConcept C126322002 @default.
• W2592877286 hasConcept C127413603 @default.
• W2592877286 hasConcept C142462285 @default.
• W2592877286 hasConcept C156719811 @default.
• W2592877286 hasConcept C159047783 @default.
• W2592877286 hasConcept C182707283 @default.
• W2592877286 hasConcept C2778451633 @default.
• W2592877286 hasConcept C2781413609 @default.
• W2592877286 hasConcept C2908647359 @default.
• W2592877286 hasConcept C2993143319 @default.
• W2592877286 hasConcept C3013748606 @default.
• W2592877286 hasConcept C49105822 @default.
• W2592877286 hasConcept C54355233 @default.
• W2592877286 hasConcept C71924100 @default.
• W2592877286 hasConcept C761482 @default.
• W2592877286 hasConcept C86803240 @default.
• W2592877286 hasConcept C89423630 @default.
• W2592877286 hasConcept C99454951 @default.
• W2592877286 hasConceptScore W2592877286C104317684 @default.
• W2592877286 hasConceptScore W2592877286C114851261 @default.
• W2592877286 hasConceptScore W2592877286C119599485 @default.
• W2592877286 hasConceptScore W2592877286C126322002 @default.
• W2592877286 hasConceptScore W2592877286C127413603 @default.
• W2592877286 hasConceptScore W2592877286C142462285 @default.
• W2592877286 hasConceptScore W2592877286C156719811 @default.

• next