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• W2592912008 abstract "Purpose The aims of this study were to evaluate the safety and pharmacokinetics of levetiracetam (LEV) in neonates with seizures and to establish a population pharmacokinetics (PPK) model by using the software NONMEM. Methods A retrospective analysis of 18 neonatal patients with seizures, who were treated with LEV, including 151 serum samples, was performed. The mean loading dose was 20 mg/kg, followed by a mean maintenance dose of 29 mg/kg/day. Results Seventeen neonates (94%) had seizure cessation within 1 week and 16 (84%) remained seizure-free at 30 days under the LEV therapy. The mean serum concentration of LEV was 8.7 µg/mL. Eight samples (5%) were found above the therapeutic range. No serious adverse effects were detected. In the PPK analysis for Korean neonates, the half-life was 9.6 hours; clearance, 0.357 L/hr; and volume of distribution, 4.947 L, showing differences from those in adults. Conclusion LEV is a safe and effective option for the treatment of neonatal seizures with careful therapeutic drug monitoring. Key words: Levetiracetam, Neonatal seizure, Population pharmacokinetics, Safety, Pharmacokinetics" @default.
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• W2592912008 date "2017-01-01" @default.
• W2592912008 modified "2023-10-16" @default.
• W2592912008 title "Experience and pharmacokinetics of Levetiracetam in Korean neonates with neonatal seizures" @default.
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• W2592912008 doi "https://doi.org/10.3345/kjp.2017.60.2.50" @default.
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