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- W2592912788 abstract "The link between cancer metabolism and immunosuppression, inflammation and immune escape has generated major interest in investigating the effects of low pH on tumor immunity. Indeed, microenvironmental acidity may differentially impact on diverse components of tumor immune surveillance, eventually contributing to immune escape and cancer progression. Although the molecular pathways underlying acidity-related immune dysfunctions are just emerging, initial evidence indicates that antitumor effectors such as T and NK cells tend to lose their function and undergo a state of mostly reversible anergy followed by apoptosis, when exposed to low pH environment. At opposite, immunosuppressive components such as myeloid cells and regulatory T cells are engaged by tumor acidity to sustain tumor growth while blocking antitumor immune responses. Local acidity could also profoundly influence bioactivity and distribution of antibodies, thus potentially interfering with the clinical efficacy of therapeutic antibodies including immune checkpoint inhibitors. Hence tumor acidity is a central regulator of cancer immunity that orchestrates both local and systemic immunosuppression and that may offer a broad panel of therapeutic targets. This review outlines the fundamental pathways of acidity-driven immune dysfunctions and sheds light on the potential strategies that could be envisaged to potentiate immune-mediated tumor control in cancer patients." @default.
- W2592912788 created "2017-03-16" @default.
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- W2592912788 date "2017-04-01" @default.
- W2592912788 modified "2023-10-13" @default.
- W2592912788 title "Cancer acidity: An ultimate frontier of tumor immune escape and a novel target of immunomodulation" @default.
- W2592912788 cites W1006554241 @default.
- W2592912788 cites W1028634185 @default.
- W2592912788 cites W1498187417 @default.
- W2592912788 cites W1505648210 @default.
- W2592912788 cites W1506816544 @default.
- W2592912788 cites W1523365630 @default.
- W2592912788 cites W1540070913 @default.
- W2592912788 cites W1544118137 @default.
- W2592912788 cites W1551906185 @default.
- W2592912788 cites W1777350112 @default.
- W2592912788 cites W1778788621 @default.
- W2592912788 cites W1821903509 @default.
- W2592912788 cites W1823780969 @default.
- W2592912788 cites W1903961798 @default.
- W2592912788 cites W1904885158 @default.
- W2592912788 cites W1923704062 @default.
- W2592912788 cites W1926568554 @default.
- W2592912788 cites W1927751365 @default.
- W2592912788 cites W1932137769 @default.
- W2592912788 cites W1965748088 @default.
- W2592912788 cites W1969057487 @default.
- W2592912788 cites W1969814796 @default.
- W2592912788 cites W1969897672 @default.
- W2592912788 cites W1970602197 @default.
- W2592912788 cites W1974035668 @default.
- W2592912788 cites W1975566288 @default.
- W2592912788 cites W1977078968 @default.
- W2592912788 cites W1981422415 @default.
- W2592912788 cites W1985355304 @default.
- W2592912788 cites W1986391308 @default.
- W2592912788 cites W1986507179 @default.
- W2592912788 cites W1986925527 @default.
- W2592912788 cites W1987133757 @default.
- W2592912788 cites W1987520066 @default.
- W2592912788 cites W1987825597 @default.
- W2592912788 cites W1988123830 @default.
- W2592912788 cites W1990265423 @default.
- W2592912788 cites W1993686673 @default.
- W2592912788 cites W1994993231 @default.
- W2592912788 cites W1995116853 @default.
- W2592912788 cites W1995943575 @default.
- W2592912788 cites W1997873174 @default.
- W2592912788 cites W1999596528 @default.
- W2592912788 cites W2000003423 @default.
- W2592912788 cites W2000323986 @default.
- W2592912788 cites W2004150448 @default.
- W2592912788 cites W2010557243 @default.
- W2592912788 cites W2011458181 @default.
- W2592912788 cites W2011810742 @default.
- W2592912788 cites W2011842971 @default.
- W2592912788 cites W2013743238 @default.
- W2592912788 cites W2014490096 @default.
- W2592912788 cites W2014986361 @default.
- W2592912788 cites W2017525816 @default.
- W2592912788 cites W2019022043 @default.
- W2592912788 cites W2019813857 @default.
- W2592912788 cites W2020199574 @default.
- W2592912788 cites W2021865808 @default.
- W2592912788 cites W2027512652 @default.
- W2592912788 cites W2029272680 @default.
- W2592912788 cites W2030028321 @default.
- W2592912788 cites W2032635767 @default.
- W2592912788 cites W2035566116 @default.
- W2592912788 cites W2039638023 @default.
- W2592912788 cites W2041092633 @default.
- W2592912788 cites W2041953257 @default.
- W2592912788 cites W2043228552 @default.
- W2592912788 cites W2046926103 @default.
- W2592912788 cites W2046959528 @default.
- W2592912788 cites W2051349300 @default.
- W2592912788 cites W2051611091 @default.
- W2592912788 cites W2051674693 @default.
- W2592912788 cites W2052401940 @default.
- W2592912788 cites W2052543023 @default.
- W2592912788 cites W2054077259 @default.
- W2592912788 cites W2054562812 @default.
- W2592912788 cites W2055769271 @default.
- W2592912788 cites W2060628991 @default.
- W2592912788 cites W2060878129 @default.
- W2592912788 cites W2063632665 @default.
- W2592912788 cites W2065677301 @default.
- W2592912788 cites W2068651607 @default.
- W2592912788 cites W2069771820 @default.