FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2592976952> ?p ?o ?g. }

• W2592976952 endingPage "58" @default.
• W2592976952 startingPage "54" @default.
• W2592976952 abstract "We examined whether apolipoprotein E (APOE) status interacts with vascular risk factors (VRFs) to predict the progression of white matter hyperintensities (WMHs) on brain MRI scans over a specific period of life in older age when the risk of dementia increases. At age 73 years, baseline VRFs were assessed via self-reported history of diabetes, hypertension, smoking, and hypercholesterolemia, and via objective measures of blood HbA1c, body mass index, diastolic and systolic blood pressure, and blood high-density lipoprotein to total cholesterol (HDL) ratio. APOE e4 allele was coded as either present or absent. WMH progression was measured on MRI over 3 years in 434 older adults, in a same-year-of-birth cohort. APOE e4 carriers with either a self-reported diagnosis of diabetes (β = 0.160, p = 0.002) or higher glycated hemoglobin levels (β = 0.114, p = 0.014) exhibited greater WMH progression, and the former survived correction for multiple testing. All other APOE-VRF interactions were nonsignificant (βinteraction < 0.056, p > 0.228). The results suggest that carrying the APOE “risk” e4 allele increases the risk of greater age-related WMH progression over the early part of the eighth decade of life, when combined with poorer glycemic control. The interaction effect was robust to co-occurring VRFs, suggesting a possible target for mitigating brain and cognitive aging at this age." @default.
• W2592976952 created "2017-03-16" @default.
• W2592976952 creator A5003194031 @default.
• W2592976952 creator A5028857433 @default.
• W2592976952 creator A5033227381 @default.
• W2592976952 creator A5034776089 @default.
• W2592976952 creator A5037656149 @default.
• W2592976952 creator A5049097607 @default.
• W2592976952 creator A5054787746 @default.
• W2592976952 creator A5061348073 @default.
• W2592976952 creator A5063484484 @default.
• W2592976952 creator A5074720746 @default.
• W2592976952 creator A5078185083 @default.
• W2592976952 creator A5078677480 @default.
• W2592976952 creator A5079216137 @default.
• W2592976952 creator A5085081184 @default.
• W2592976952 creator A5088031899 @default.
• W2592976952 date "2017-06-01" @default.
• W2592976952 modified "2023-10-06" @default.
• W2592976952 title "Interaction of APOE e4 and poor glycemic control predicts white matter hyperintensity growth from 73 to 76" @default.
• W2592976952 cites W1980991473 @default.
• W2592976952 cites W1982947392 @default.
• W2592976952 cites W1994137501 @default.
• W2592976952 cites W1998016711 @default.
• W2592976952 cites W1999288550 @default.
• W2592976952 cites W2002408824 @default.
• W2592976952 cites W2006534012 @default.
• W2592976952 cites W2008273493 @default.
• W2592976952 cites W2009339691 @default.
• W2592976952 cites W2014614026 @default.
• W2592976952 cites W2023728161 @default.
• W2592976952 cites W2034510106 @default.
• W2592976952 cites W2036028637 @default.
• W2592976952 cites W2036717027 @default.
• W2592976952 cites W2054692171 @default.
• W2592976952 cites W2060803759 @default.
• W2592976952 cites W2074249519 @default.
• W2592976952 cites W2089435027 @default.
• W2592976952 cites W2091041552 @default.
• W2592976952 cites W2091163929 @default.
• W2592976952 cites W2092997689 @default.
• W2592976952 cites W2100358124 @default.
• W2592976952 cites W2102277625 @default.
• W2592976952 cites W2102811819 @default.
• W2592976952 cites W2102838347 @default.
• W2592976952 cites W2111958870 @default.
• W2592976952 cites W2121101037 @default.
• W2592976952 cites W2122477279 @default.
• W2592976952 cites W2124686490 @default.
• W2592976952 cites W2131078911 @default.
• W2592976952 cites W2131298552 @default.
• W2592976952 cites W2140575485 @default.
• W2592976952 cites W2147363246 @default.
• W2592976952 cites W2149369886 @default.
• W2592976952 cites W2152488179 @default.
• W2592976952 cites W2158742097 @default.
• W2592976952 cites W2304740645 @default.
• W2592976952 cites W2309640507 @default.
• W2592976952 cites W2320715666 @default.
• W2592976952 cites W2518774723 @default.
• W2592976952 doi "https://doi.org/10.1016/j.neurobiolaging.2017.02.014" @default.
• W2592976952 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5407886" @default.
• W2592976952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28324763" @default.
• W2592976952 hasPublicationYear "2017" @default.
• W2592976952 type Work @default.
• W2592976952 sameAs 2592976952 @default.
• W2592976952 citedByCount "19" @default.
• W2592976952 countsByYear W25929769522017 @default.
• W2592976952 countsByYear W25929769522018 @default.
• W2592976952 countsByYear W25929769522019 @default.
• W2592976952 countsByYear W25929769522020 @default.
• W2592976952 countsByYear W25929769522021 @default.
• W2592976952 countsByYear W25929769522022 @default.
• W2592976952 countsByYear W25929769522023 @default.
• W2592976952 crossrefType "journal-article" @default.
• W2592976952 hasAuthorship W2592976952A5003194031 @default.
• W2592976952 hasAuthorship W2592976952A5028857433 @default.
• W2592976952 hasAuthorship W2592976952A5033227381 @default.
• W2592976952 hasAuthorship W2592976952A5034776089 @default.
• W2592976952 hasAuthorship W2592976952A5037656149 @default.
• W2592976952 hasAuthorship W2592976952A5049097607 @default.
• W2592976952 hasAuthorship W2592976952A5054787746 @default.
• W2592976952 hasAuthorship W2592976952A5061348073 @default.
• W2592976952 hasAuthorship W2592976952A5063484484 @default.
• W2592976952 hasAuthorship W2592976952A5074720746 @default.
• W2592976952 hasAuthorship W2592976952A5078185083 @default.
• W2592976952 hasAuthorship W2592976952A5078677480 @default.
• W2592976952 hasAuthorship W2592976952A5079216137 @default.
• W2592976952 hasAuthorship W2592976952A5085081184 @default.
• W2592976952 hasAuthorship W2592976952A5088031899 @default.
• W2592976952 hasBestOaLocation W25929769521 @default.
• W2592976952 hasConcept C126322002 @default.
• W2592976952 hasConcept C126838900 @default.
• W2592976952 hasConcept C134018914 @default.
• W2592976952 hasConcept C143409427 @default.
• W2592976952 hasConcept C146638467 @default.
• W2592976952 hasConcept C164705383 @default.
• W2592976952 hasConcept C2777180221 @default.

• next