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• W2592982749 abstract "Microsatellite-unstable colorectal cancers (CRC) that are due to deficient DNA mismatch repair (dMMR) represent approximately 15% of all CRCs in the United States. These microsatellite-unstable CRCs represent a heterogenous group of diseases with distinct oncogenesis pathways. There are overlapping clinicopathologic features between some of these groups, but many important differences are present. Therefore, determination of the etiology for the dMMR is vital for proper patient management and follow-up.Epigenetic inactivation of MLH1 MMR gene (sporadic microsatellite-unstable CRC) and germline mutation in an MMR gene (Lynch syndrome, LS) are the two most common mechanisms in the pathogenesis of microsatellite instability in CRC. However, in a subset of dMMR CRC cases that are identified by screening tests, no known LS-associated genetic alterations are appreciated by current genetic analysis. When the etiology for dMMR is unclear, it leads to patient anxiety and creates challenges for clinical management.It is critical to distinguish LS patients from other patients with tumors due to dMMR, so that the proper screening protocol can be employed for the patients and their families, with the goal to save lives while avoiding unnecessary anxiety and costs. This review summarizes the major pathogenesis pathways of dMMR CRCs, their clinicopathologic features, and practical screening suggestions. In addition, we include frequently asked questions for MMR immunohistochemistry interpretation." @default.
• W2592982749 created "2017-03-16" @default.
• W2592982749 creator A5017541508 @default.
• W2592982749 creator A5049172627 @default.
• W2592982749 creator A5061124226 @default.
• W2592982749 date "2017-03-04" @default.
• W2592982749 modified "2023-10-14" @default.
• W2592982749 title "Molecular genetics of microsatellite-unstable colorectal cancer for pathologists" @default.
• W2592982749 cites W1163015159 @default.
• W2592982749 cites W1215364715 @default.
• W2592982749 cites W128970900 @default.
• W2592982749 cites W1504535992 @default.
• W2592982749 cites W1663153674 @default.
• W2592982749 cites W1779852197 @default.
• W2592982749 cites W1893792948 @default.
• W2592982749 cites W1926715094 @default.
• W2592982749 cites W1940241680 @default.
• W2592982749 cites W1965997942 @default.
• W2592982749 cites W1966498049 @default.
• W2592982749 cites W1968028641 @default.
• W2592982749 cites W1972254989 @default.
• W2592982749 cites W1986937402 @default.
• W2592982749 cites W1988790156 @default.
• W2592982749 cites W1993051520 @default.
• W2592982749 cites W1998810104 @default.
• W2592982749 cites W2003056152 @default.
• W2592982749 cites W2004140222 @default.
• W2592982749 cites W2006149098 @default.
• W2592982749 cites W2013475854 @default.
• W2592982749 cites W2026895762 @default.
• W2592982749 cites W2030215939 @default.
• W2592982749 cites W2032465462 @default.
• W2592982749 cites W2035237521 @default.
• W2592982749 cites W2036041958 @default.
• W2592982749 cites W2039376120 @default.
• W2592982749 cites W2040610908 @default.
• W2592982749 cites W2044386531 @default.
• W2592982749 cites W2045044035 @default.
• W2592982749 cites W2048159378 @default.
• W2592982749 cites W2048179657 @default.
• W2592982749 cites W2056543072 @default.
• W2592982749 cites W2057822920 @default.
• W2592982749 cites W2058432715 @default.
• W2592982749 cites W2058438744 @default.
• W2592982749 cites W2062850641 @default.
• W2592982749 cites W2064329151 @default.
• W2592982749 cites W2065785936 @default.
• W2592982749 cites W2069054764 @default.
• W2592982749 cites W2081427090 @default.
• W2592982749 cites W2083097481 @default.
• W2592982749 cites W2093524469 @default.
• W2592982749 cites W2095878672 @default.
• W2592982749 cites W2096551220 @default.
• W2592982749 cites W2096857955 @default.
• W2592982749 cites W2097222740 @default.
• W2592982749 cites W2103982179 @default.
• W2592982749 cites W2106832044 @default.
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• W2592982749 cites W2152344392 @default.
• W2592982749 cites W2153652529 @default.
• W2592982749 cites W2154546296 @default.
• W2592982749 cites W2162077547 @default.
• W2592982749 cites W2168381135 @default.
• W2592982749 cites W2168680994 @default.
• W2592982749 cites W2169903102 @default.
• W2592982749 cites W2188312187 @default.
• W2592982749 cites W2207978442 @default.
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• W2592982749 doi "https://doi.org/10.1186/s13000-017-0613-8" @default.
• W2592982749 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5336657" @default.
• W2592982749 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28259170" @default.
• W2592982749 hasPublicationYear "2017" @default.
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