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- W2592996599 abstract "Abstract After the introduction of trastuzumab, a monoclonal antibody that binds to human epidermal growth factor receptor 2 (HER2), the overall survival (OS) among patients with HER2‐positive breast cancer has been substantially improved. However, among these patients, the incidence of brain metastases (BM) has been increasing and an increased proportion of them have died of intracranial progression, which makes HER2‐positive breast cancer brain metastases (BCBM) a critical issue of concern. For local control of limited BM, stereotactic radiosurgery (SRS) and surgical resection are available modalities with different clinical indications. Postoperative or preoperative radiation is usually delivered in conjunction with surgical resection to boost local control. Adjuvant whole‐brain radiotherapy (WBRT) should be deferred for limited BM because of its impairment of neurocognitive function while having no benefit for OS. Although WBRT is still the standard treatment for local control of diffuse BM, SRS is a promising treatment for diffuse BM as the technique continues to improve. Although large molecules have difficulty crossing the blood brain barrier, trastuzumab‐containing regimens are critical for treating HER2‐positive BCBM patients because they significantly prolong OS. Tyrosine kinase inhibitors are more capable of crossing into the brain and they have been shown to be beneficial for treating BM in HER2‐positive patients, especially lapatinib combined with capecitabine. The antiangiogenic agent, bevacizumab, can be applied in the HER2‐positive BCBM scenario as well. In this review, we also discuss several strategies for delivering drugs into the central nervous system and several microRNAs that have the potential to become biomarkers of BCBM." @default.
- W2592996599 created "2017-03-16" @default.
- W2592996599 creator A5020337517 @default.
- W2592996599 creator A5059906168 @default.
- W2592996599 date "2017-03-01" @default.
- W2592996599 modified "2023-09-26" @default.
- W2592996599 title "Management of breast cancer brain metastases: Focus on human epidermal growth factor receptor 2‐positive breast cancer" @default.
- W2592996599 cites W121353936 @default.
- W2592996599 cites W1513915183 @default.
- W2592996599 cites W169246983 @default.
- W2592996599 cites W1840283672 @default.
- W2592996599 cites W1965618711 @default.
- W2592996599 cites W1966116761 @default.
- W2592996599 cites W1974820090 @default.
- W2592996599 cites W1975355918 @default.
- W2592996599 cites W1976324983 @default.
- W2592996599 cites W1976446970 @default.
- W2592996599 cites W1979362025 @default.
- W2592996599 cites W1980588116 @default.
- W2592996599 cites W1984007145 @default.
- W2592996599 cites W1984221014 @default.
- W2592996599 cites W1985351938 @default.
- W2592996599 cites W1994374489 @default.
- W2592996599 cites W1995255172 @default.
- W2592996599 cites W1998148432 @default.
- W2592996599 cites W2003917401 @default.
- W2592996599 cites W2004112197 @default.
- W2592996599 cites W2005363427 @default.
- W2592996599 cites W2006154529 @default.
- W2592996599 cites W2007346653 @default.
- W2592996599 cites W2008126023 @default.
- W2592996599 cites W2009949105 @default.
- W2592996599 cites W2012945281 @default.
- W2592996599 cites W2013073222 @default.
- W2592996599 cites W2013513553 @default.
- W2592996599 cites W2013669698 @default.
- W2592996599 cites W2015593424 @default.
- W2592996599 cites W2015847442 @default.
- W2592996599 cites W2017847845 @default.
- W2592996599 cites W2018110352 @default.
- W2592996599 cites W2021156935 @default.
- W2592996599 cites W2024153488 @default.
- W2592996599 cites W2027092408 @default.
- W2592996599 cites W2029738976 @default.
- W2592996599 cites W2035570331 @default.
- W2592996599 cites W2037873158 @default.
- W2592996599 cites W2044579127 @default.
- W2592996599 cites W2045134790 @default.
- W2592996599 cites W2045869644 @default.
- W2592996599 cites W2061962226 @default.
- W2592996599 cites W2063376924 @default.
- W2592996599 cites W2064006344 @default.
- W2592996599 cites W2073597965 @default.
- W2592996599 cites W2073910638 @default.
- W2592996599 cites W2078074220 @default.
- W2592996599 cites W2079983671 @default.
- W2592996599 cites W2080507441 @default.
- W2592996599 cites W2083485971 @default.
- W2592996599 cites W2083675583 @default.
- W2592996599 cites W2093447167 @default.
- W2592996599 cites W2098208110 @default.
- W2592996599 cites W2098256073 @default.
- W2592996599 cites W2098677385 @default.
- W2592996599 cites W2102149158 @default.
- W2592996599 cites W2103148512 @default.
- W2592996599 cites W2107499699 @default.
- W2592996599 cites W2107529266 @default.
- W2592996599 cites W2108739598 @default.
- W2592996599 cites W2109176076 @default.
- W2592996599 cites W2111406583 @default.
- W2592996599 cites W2114080253 @default.
- W2592996599 cites W2115425452 @default.
- W2592996599 cites W2116760308 @default.
- W2592996599 cites W2118600577 @default.
- W2592996599 cites W2121516377 @default.
- W2592996599 cites W2125736017 @default.
- W2592996599 cites W2126743110 @default.
- W2592996599 cites W2127199535 @default.
- W2592996599 cites W2127657464 @default.
- W2592996599 cites W2127714076 @default.
- W2592996599 cites W2128871519 @default.
- W2592996599 cites W2129060478 @default.
- W2592996599 cites W2129749518 @default.
- W2592996599 cites W2130735457 @default.
- W2592996599 cites W2131359324 @default.
- W2592996599 cites W2131558896 @default.
- W2592996599 cites W2134031795 @default.
- W2592996599 cites W2135890715 @default.
- W2592996599 cites W2137228442 @default.
- W2592996599 cites W2137367775 @default.
- W2592996599 cites W2141590659 @default.
- W2592996599 cites W2141604895 @default.
- W2592996599 cites W2143184226 @default.
- W2592996599 cites W2144686284 @default.
- W2592996599 cites W2145224595 @default.
- W2592996599 cites W2152142449 @default.
- W2592996599 cites W2153140684 @default.
- W2592996599 cites W2154563173 @default.