FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2593012972> ?p ?o ?g. }

• W2593012972 endingPage "1200" @default.
• W2593012972 startingPage "1193" @default.
• W2593012972 abstract "It is unclear whether the efficacy and long-term outcome of treating patients with hepatitis C virus (HCV)-positive cirrhosis with the new protease inhibitors will extend to those with Child C cirrhosis.To assess the effectiveness of the interferon-free regimens in Child C cirrhotic patients with HCV infection.A systematic Medline search was conducted to retrieve studies describing the treatment of Child C patients with direct-acting agents. Citations from identified studies were cross-referenced and abstracts from European Association for the Study of the Liver (EASL) and American Association for the Study of Liver Disease (AASLD) meetings were checked. Extracted data were evaluated using a meta-analysis to calculate a weighted response rate.Seven full-text records and two conference abstracts were retained for analysis from the 649 records identified. Data from an Italian real-life trial were also interrogated. Information on treatment outcome was available for 228 of the 240 Child C patients evaluated in the 10 trials. Overall, the weighted mean sustained virological response (SVR12) was 74.9% (95% CI: 65.6-82.4%). Neither duration of treatment (24 or 12 weeks), nor addition of ribavirin influenced these rates. The weighted SVR12 was 65.4% (95% CI: 46.8-80.2) after sofosbuvir/simeprevir, 76.0% (95% CI: 54.4-89.3%) after sofosbuvir/daclatasvir and 83.0% (95% CI: 73.4-89.6) after sofosbuvir/ledipasvir. Some studies did not provide information on the rate of post-treatment relapse or functional improvement. However, in those studies that did provide such data, a relapse was documented in 12.1% of patients and an improvement of ≥2 points on the model for end-stage liver disease (MELD) score in 61.1% of patients.The improvement in MELD scores strongly suggests HCV-positive patients with Child C cirrhosis should be treated with these agents." @default.
• W2593012972 created "2017-03-16" @default.
• W2593012972 creator A5001098190 @default.
• W2593012972 creator A5003275279 @default.
• W2593012972 creator A5008683685 @default.
• W2593012972 creator A5015267957 @default.
• W2593012972 creator A5016055227 @default.
• W2593012972 creator A5024660712 @default.
• W2593012972 creator A5030372213 @default.
• W2593012972 creator A5057664702 @default.
• W2593012972 creator A5066256570 @default.
• W2593012972 creator A5067249056 @default.
• W2593012972 creator A5069315930 @default.
• W2593012972 creator A5084332947 @default.
• W2593012972 date "2017-03-06" @default.
• W2593012972 modified "2023-10-02" @default.
• W2593012972 title "Systematic review: interferon-free regimens for patients with HCV-related Child C cirrhosis" @default.
• W2593012972 cites W1598602811 @default.
• W2593012972 cites W1837435324 @default.
• W2593012972 cites W1881390415 @default.
• W2593012972 cites W1894101563 @default.
• W2593012972 cites W1922890115 @default.
• W2593012972 cites W1954289452 @default.
• W2593012972 cites W1980154502 @default.
• W2593012972 cites W1990451432 @default.
• W2593012972 cites W2001428654 @default.
• W2593012972 cites W2004009551 @default.
• W2593012972 cites W2015973940 @default.
• W2593012972 cites W2019946868 @default.
• W2593012972 cites W2020018978 @default.
• W2593012972 cites W2108003107 @default.
• W2593012972 cites W2114228887 @default.
• W2593012972 cites W2117766751 @default.
• W2593012972 cites W2145933460 @default.
• W2593012972 cites W2147744539 @default.
• W2593012972 cites W2159845343 @default.
• W2593012972 cites W2183784190 @default.
• W2593012972 cites W2277396963 @default.
• W2593012972 cites W2306227468 @default.
• W2593012972 cites W2325297898 @default.
• W2593012972 cites W2472585716 @default.
• W2593012972 cites W2516795023 @default.
• W2593012972 cites W2520394128 @default.
• W2593012972 cites W2540370990 @default.
• W2593012972 cites W2549046420 @default.
• W2593012972 cites W2604161404 @default.
• W2593012972 doi "https://doi.org/10.1111/apt.14017" @default.
• W2593012972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28261822" @default.
• W2593012972 hasPublicationYear "2017" @default.
• W2593012972 type Work @default.
• W2593012972 sameAs 2593012972 @default.
• W2593012972 citedByCount "21" @default.
• W2593012972 countsByYear W25930129722017 @default.
• W2593012972 countsByYear W25930129722018 @default.
• W2593012972 countsByYear W25930129722019 @default.
• W2593012972 countsByYear W25930129722020 @default.
• W2593012972 countsByYear W25930129722021 @default.
• W2593012972 countsByYear W25930129722022 @default.
• W2593012972 crossrefType "journal-article" @default.
• W2593012972 hasAuthorship W2593012972A5001098190 @default.
• W2593012972 hasAuthorship W2593012972A5003275279 @default.
• W2593012972 hasAuthorship W2593012972A5008683685 @default.
• W2593012972 hasAuthorship W2593012972A5015267957 @default.
• W2593012972 hasAuthorship W2593012972A5016055227 @default.
• W2593012972 hasAuthorship W2593012972A5024660712 @default.
• W2593012972 hasAuthorship W2593012972A5030372213 @default.
• W2593012972 hasAuthorship W2593012972A5057664702 @default.
• W2593012972 hasAuthorship W2593012972A5066256570 @default.
• W2593012972 hasAuthorship W2593012972A5067249056 @default.
• W2593012972 hasAuthorship W2593012972A5069315930 @default.
• W2593012972 hasAuthorship W2593012972A5084332947 @default.
• W2593012972 hasBestOaLocation W25930129721 @default.
• W2593012972 hasConcept C126322002 @default.
• W2593012972 hasConcept C159047783 @default.
• W2593012972 hasConcept C2522874641 @default.
• W2593012972 hasConcept C2775999097 @default.
• W2593012972 hasConcept C2776408679 @default.
• W2593012972 hasConcept C2776455275 @default.
• W2593012972 hasConcept C2776979040 @default.
• W2593012972 hasConcept C2777075537 @default.
• W2593012972 hasConcept C2777214474 @default.
• W2593012972 hasConcept C2778390639 @default.
• W2593012972 hasConcept C2778986448 @default.
• W2593012972 hasConcept C2780040827 @default.
• W2593012972 hasConcept C71924100 @default.
• W2593012972 hasConcept C90924648 @default.
• W2593012972 hasConceptScore W2593012972C126322002 @default.
• W2593012972 hasConceptScore W2593012972C159047783 @default.
• W2593012972 hasConceptScore W2593012972C2522874641 @default.
• W2593012972 hasConceptScore W2593012972C2775999097 @default.
• W2593012972 hasConceptScore W2593012972C2776408679 @default.
• W2593012972 hasConceptScore W2593012972C2776455275 @default.
• W2593012972 hasConceptScore W2593012972C2776979040 @default.
• W2593012972 hasConceptScore W2593012972C2777075537 @default.
• W2593012972 hasConceptScore W2593012972C2777214474 @default.
• W2593012972 hasConceptScore W2593012972C2778390639 @default.
• W2593012972 hasConceptScore W2593012972C2778986448 @default.
• W2593012972 hasConceptScore W2593012972C2780040827 @default.

• next