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- W2593025218 abstract "Zehneria scarba is one of the medicinal plants used in folkloric medicine of Ethiopia for yearsto treat various inflammatory disorders. Even though the anti-inflammatory activity of thecrude hydroalcoholic extract of the leaves of this plant was evaluated against acute model ofinflammation, no further work has been done to screen the anti-inflammatory activities of thecrude extract and solvent fractions on subacute and chronic models of inflammation. Thepresent study was, therefore, aimed to further validate the anti-inflammatory activity of crude70% ethanol leaves extract (70EE) against a sub-acute model and further evaluate the solventfractions (AF, BF and CF) in an acute (carrageenan induced paw edema), sub-acute(formaldehyde induced arthritis) and chronic (cotton pellet induced granuloma) inflammatorymodels. The 70EE was first prepared by maceration, and the fractions were obtained bysequential partitioning with chloroform and n-butanol from the aqueous suspension of crude70EE. The test groups, then, received 100, 200 and 400 mg/kg of the crude 70EE or thefractions (AF, BF, and CF) at the same dose levels, whereas positive controls received aspirin(200mg/kg) or dexamethasone (0.5mg/kg) and negative controls received vehicle (2% tween80 or distilled water, 10 ml/kg). All tested doses of the crude 70EE showed a significantinhibition of formaldehyde induced arthritis at the 10th day of treatment; on which the400mg/kg dose showed the maximum anti-arthritic effect (%A = 60.5; p < 0.001). In thecarrageenan induced paw edema all the three fractions showed a statistically significant effect,in fact, with different onset and magnitude. In this model the AF was found to be the mostactive fraction, and the 400mg/kg dose demonstrated the maximum effect (%A = 76.25; p <0.001) at 5h post induction which is much better than the effect of aspirin at the doseemployed. The overall order of efficacy in inhibiting the exudative component of carrageenaninduced paw edema was found to be AF > BF > CF. The AF was also found to be the mostactive fraction in inhibiting the exudative component of chronic inflammation in the cottonpellet induced granuloma model, where the maximum effect (%A = 43.10, p < 0.001) wasexhibited by dose of 400mg/kg. The AF was also the most active fraction in inhibitingformaldehyde induced arthritis, in which the BF and CF relatively showed a comparableeffect throughout day 4-10. On the contrary, in the cotton pellet induced granuloma model,the CF was found to be the most active fraction in inhibiting the proliferative andgranulomatous component of chronic inflammation, and the overall order of effectiveness wasfound to be CF > AF > BF. Besides, 400mg/kg of CF demonstrated the maximum inhibitionof granuloma formation (%A = 55.52; P < 0.001). The phytochemical analysis revealeddifferential distribution of secondary metabolites into the three fractions which either singlyor in concert appeared to be responsible for the observed effects. The data obtained from thepresent study collectively indicate that the extract and fractions of leaves of Z.scabrapossessed a significant anti-inflammatory activity, upholding the folkloric use of the plant." @default.
- W2593025218 created "2017-03-16" @default.
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- W2593025218 date "2016-06-01" @default.
- W2593025218 modified "2023-09-26" @default.
- W2593025218 title "Evaluation of the Anti-Inflammatory Activities of 70% Ethanol Leaves Extract and Solvent Fractions of Zehneria Scabra (L.F.) Sond (Cucurbitaceae) In Rodents" @default.
- W2593025218 hasPublicationYear "2016" @default.
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