FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2593074107> ?p ?o ?g. }

• W2593074107 endingPage "43" @default.
• W2593074107 startingPage "38" @default.
• W2593074107 abstract "Inter-individual variability in the host response contributes significantly to expression of periodontal disease. Thus, research into the human host response is considered important in the analysis of periodontal disease. Human β-defensin-2 (hBD-2) is typically produced by epithelial tissues after stimulation with microorganisms and inflammatory mediators, and it contributes to the initial defense in the innate immune response. However, hBD-2 expression in response to infection has not been investigated in human gingival tissue with periodontitis. We examined the response to Porphyromonas gingivalis in an established in vivo model of human gingival grafts with various degrees of periodontitis. We also investigated the expression profile of interleukin-1β (IL-1β). Gingival tissues were collected from 40 patients with chronic periodontitis (21 with slight-to-moderate disease, 19 with severe disease) during tooth extraction or periodontal surgery. These tissues were transplanted subcutaneously into nu/nu mice. We used real-time PCR to compare the expression of hBD-2 and IL-1β. In slight-to-moderate chronic periodontitis, hBD-2 expression was significantly higher in the stimulated group than in the non-stimulated group (p < 0.05), but there was no significant increase in the group with severe chronic periodontitis. IL-1β expression did not differ between groups. Increased expression of hBD-2 and IL-1β was associated with slight-to-moderate periodontitis (p < 0.05), and there was a significant relationship between decreased hBD-2 and IL-1β expression and severe periodontitis (p < 0.05). The initial expression profile of hBD-2 in P. gingivalis infection differs according to the severity of periodontitis. In addition, changes in hBD-2 and IL-1β expression may be important in the progression of periodontitis." @default.
• W2593074107 created "2017-03-16" @default.
• W2593074107 creator A5011832607 @default.
• W2593074107 creator A5012588636 @default.
• W2593074107 creator A5013512585 @default.
• W2593074107 creator A5018507557 @default.
• W2593074107 creator A5049282731 @default.
• W2593074107 creator A5053783093 @default.
• W2593074107 creator A5068253707 @default.
• W2593074107 creator A5086890374 @default.
• W2593074107 date "2017-06-01" @default.
• W2593074107 modified "2023-10-16" @default.
• W2593074107 title "Human β-defensin-2 and interleukin-1β expression in response to Porphyromonas gingivalis challenge in mice transplanted with periodontitic human gingiva" @default.
• W2593074107 cites W1647699403 @default.
• W2593074107 cites W1844316610 @default.
• W2593074107 cites W1977317630 @default.
• W2593074107 cites W1998197722 @default.
• W2593074107 cites W2006714439 @default.
• W2593074107 cites W2009389421 @default.
• W2593074107 cites W2028635293 @default.
• W2593074107 cites W2039124919 @default.
• W2593074107 cites W2042265577 @default.
• W2593074107 cites W2062545543 @default.
• W2593074107 cites W2070809257 @default.
• W2593074107 cites W2075060640 @default.
• W2593074107 cites W2077768378 @default.
• W2593074107 cites W2080526016 @default.
• W2593074107 cites W2121198373 @default.
• W2593074107 cites W2121902539 @default.
• W2593074107 cites W2128005102 @default.
• W2593074107 cites W2129867662 @default.
• W2593074107 cites W2140151651 @default.
• W2593074107 cites W2152963387 @default.
• W2593074107 cites W2158011720 @default.
• W2593074107 cites W2161180045 @default.
• W2593074107 cites W2168874564 @default.
• W2593074107 cites W2170442599 @default.
• W2593074107 cites W2174784305 @default.
• W2593074107 doi "https://doi.org/10.1016/j.micpath.2017.03.008" @default.
• W2593074107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28286291" @default.
• W2593074107 hasPublicationYear "2017" @default.
• W2593074107 type Work @default.
• W2593074107 sameAs 2593074107 @default.
• W2593074107 citedByCount "2" @default.
• W2593074107 countsByYear W25930741072018 @default.
• W2593074107 countsByYear W25930741072020 @default.
• W2593074107 crossrefType "journal-article" @default.
• W2593074107 hasAuthorship W2593074107A5011832607 @default.
• W2593074107 hasAuthorship W2593074107A5012588636 @default.
• W2593074107 hasAuthorship W2593074107A5013512585 @default.
• W2593074107 hasAuthorship W2593074107A5018507557 @default.
• W2593074107 hasAuthorship W2593074107A5049282731 @default.
• W2593074107 hasAuthorship W2593074107A5053783093 @default.
• W2593074107 hasAuthorship W2593074107A5068253707 @default.
• W2593074107 hasAuthorship W2593074107A5086890374 @default.
• W2593074107 hasBestOaLocation W25930741072 @default.
• W2593074107 hasConcept C129437159 @default.
• W2593074107 hasConcept C136449434 @default.
• W2593074107 hasConcept C199343813 @default.
• W2593074107 hasConcept C203014093 @default.
• W2593074107 hasConcept C2776498113 @default.
• W2593074107 hasConcept C2778690821 @default.
• W2593074107 hasConcept C2779337755 @default.
• W2593074107 hasConcept C2780183776 @default.
• W2593074107 hasConcept C2780385504 @default.
• W2593074107 hasConcept C4937899 @default.
• W2593074107 hasConcept C71924100 @default.
• W2593074107 hasConcept C74172505 @default.
• W2593074107 hasConcept C86803240 @default.
• W2593074107 hasConcept C8891405 @default.
• W2593074107 hasConcept C89423630 @default.
• W2593074107 hasConceptScore W2593074107C129437159 @default.
• W2593074107 hasConceptScore W2593074107C136449434 @default.
• W2593074107 hasConceptScore W2593074107C199343813 @default.
• W2593074107 hasConceptScore W2593074107C203014093 @default.
• W2593074107 hasConceptScore W2593074107C2776498113 @default.
• W2593074107 hasConceptScore W2593074107C2778690821 @default.
• W2593074107 hasConceptScore W2593074107C2779337755 @default.
• W2593074107 hasConceptScore W2593074107C2780183776 @default.
• W2593074107 hasConceptScore W2593074107C2780385504 @default.
• W2593074107 hasConceptScore W2593074107C4937899 @default.
• W2593074107 hasConceptScore W2593074107C71924100 @default.
• W2593074107 hasConceptScore W2593074107C74172505 @default.
• W2593074107 hasConceptScore W2593074107C86803240 @default.
• W2593074107 hasConceptScore W2593074107C8891405 @default.
• W2593074107 hasConceptScore W2593074107C89423630 @default.
• W2593074107 hasLocation W25930741071 @default.
• W2593074107 hasLocation W25930741072 @default.
• W2593074107 hasLocation W25930741073 @default.
• W2593074107 hasLocation W25930741074 @default.
• W2593074107 hasLocation W25930741075 @default.
• W2593074107 hasOpenAccess W2593074107 @default.
• W2593074107 hasPrimaryLocation W25930741071 @default.
• W2593074107 hasRelatedWork W2006440275 @default.
• W2593074107 hasRelatedWork W2009389421 @default.
• W2593074107 hasRelatedWork W2048942027 @default.
• W2593074107 hasRelatedWork W2099231959 @default.
• W2593074107 hasRelatedWork W2360736498 @default.

• next