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- W2593130565 abstract "Objective: To investigate the effectiveness of liposomal dl-α-tocopherol in a topical delivery system. Methods: A Franz diffusion cell was used for in vitro permeation studies using an excised pig ear or a cellophane membrane. The membrane permeability of dl-α-tocopherol was evaluated with three formulations: 1. dl-α-tocopherol incorporated macro emulsion, 2. dl-α-tocopherol encapsulated liposome and 3. Liposomal dl-α-tocopherolin corporated macro emulsion, each consisting of 0.05%(w/v)dl-α-tocopherol. The receiver solution was phosphate buffered saline (PBS). Permeability studies were carried out for 5 and 24 hours with the pig ear and cellophane membrane, respectively. Results: Liposomes in macro emulsion showed the highest permeability compared to other formulations. Average membrane permeability values (Kp) for formulations 1, 2 and 3 with the pig ear were 5.8 × 10-6 cm min-1, 9.3 × 10-6 cm min-1 and 3.7 × 10-3cm min-1, respectively. The average permeability values for the three formulations 1, 2 and 3 with the cellophane membrane were 1.3 × 10-6 cm min-1, 1.6 × 10-6 cm min-1 and 2.6 × 10-6 cm min-1 Conclusion: These results suggest that incorporation of liposomal dl-α-tocopherol in macro emulsions is more effective than mere addition of dl-αtocopherol in emulsions,for topical delivery of vitamin E. , respectively." @default.
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- W2593130565 date "2014-01-01" @default.
- W2593130565 modified "2023-09-27" @default.
- W2593130565 title "IMPROVED SKIN PERMEABILITY OF DL-α-TOCOPHEROL IN TOPICAL MACRO EMULSIONS" @default.
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