FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2593174977> ?p ?o ?g. }

• W2593174977 endingPage "288" @default.
• W2593174977 startingPage "276" @default.
• W2593174977 abstract "Fecal microbiota transplantation (FMT) is a highly effective treatment of recurrent and recalcitrant Clostridium difficile infection (rCDI). In a recent study oral-delivery of encapsulated, freeze-dried donor material, resulted in comparable rates of cure to colonoscopic approaches. Here we characterize shifts in the fecal bacterial community structure of patients treated for rCDI using encapsulated donor material. Prior to FMT, patient fecal samples showed declines in diversity and abundance of Firmicutes and Bacteroidetes, with concurrent increases in members of the Proteobacteria, specifically Enterobacteriaceae. Moreover, patients who experienced recurrence of CDI within the 2-month clinical follow-up had greater abundances of Enterobacteriaceae and did not show resolution of dysbioses. Despite resolution of rCDI following oral-administration of encapsulated fecal microbiota, community composition was slow to return to a normal donor-like assemblage. Post-FMT taxa within the Firmicutes showed rapid increases in relative abundance and did not vary significantly over time. Conversely, Bacteroidetes taxa only showed significant increases in abundance after one month post-FMT, corresponding to significant increases in the community attributable to the donors. Changes in the associations among dominant OTUs were observed at days, weeks, and months post-FMT, suggesting shifts in community dynamics may be related to the timing of increases in abundance of specific taxa. Administration of encapsulated, freeze-dried, fecal microbiota to rCDI patients resulted in restoration of bacterial diversity and resolution of dysbiosis. However, shifts in the fecal microbiome were incremental rather than immediate, and may be driven by changes in community dynamics reflecting changes in the host environment." @default.
• W2593174977 created "2017-03-16" @default.
• W2593174977 creator A5000629386 @default.
• W2593174977 creator A5028706102 @default.
• W2593174977 creator A5039715677 @default.
• W2593174977 creator A5055546724 @default.
• W2593174977 creator A5060451719 @default.
• W2593174977 creator A5064370193 @default.
• W2593174977 creator A5073190439 @default.
• W2593174977 creator A5082167284 @default.
• W2593174977 creator A5085574989 @default.
• W2593174977 date "2017-02-28" @default.
• W2593174977 modified "2023-10-17" @default.
• W2593174977 title "Community dynamics drive punctuated engraftment of the fecal microbiome following transplantation using freeze-dried, encapsulated fecal microbiota" @default.
• W2593174977 cites W1919772617 @default.
• W2593174977 cites W1946921525 @default.
• W2593174977 cites W1972856040 @default.
• W2593174977 cites W1975176103 @default.
• W2593174977 cites W1993830991 @default.
• W2593174977 cites W2005844485 @default.
• W2593174977 cites W2033649854 @default.
• W2593174977 cites W2049506766 @default.
• W2593174977 cites W2054407804 @default.
• W2593174977 cites W2087671769 @default.
• W2593174977 cites W2087897706 @default.
• W2593174977 cites W2088781465 @default.
• W2593174977 cites W2091922579 @default.
• W2593174977 cites W2095132285 @default.
• W2593174977 cites W2098897627 @default.
• W2593174977 cites W2099053943 @default.
• W2593174977 cites W2108718991 @default.
• W2593174977 cites W2109127169 @default.
• W2593174977 cites W2113977541 @default.
• W2593174977 cites W2119114528 @default.
• W2593174977 cites W2120501335 @default.
• W2593174977 cites W2122674349 @default.
• W2593174977 cites W2136879569 @default.
• W2593174977 cites W2147618390 @default.
• W2593174977 cites W2148171446 @default.
• W2593174977 cites W2150914285 @default.
• W2593174977 cites W2155066423 @default.
• W2593174977 cites W2155378208 @default.
• W2593174977 cites W2156875941 @default.
• W2593174977 cites W2159675211 @default.
• W2593174977 cites W2235498129 @default.
• W2593174977 cites W2310948435 @default.
• W2593174977 cites W2512704070 @default.
• W2593174977 cites W2529638643 @default.
• W2593174977 cites W2567261527 @default.
• W2593174977 cites W2588596701 @default.
• W2593174977 cites W620481910 @default.
• W2593174977 doi "https://doi.org/10.1080/19490976.2017.1299310" @default.
• W2593174977 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5479395" @default.
• W2593174977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28282270" @default.
• W2593174977 hasPublicationYear "2017" @default.
• W2593174977 type Work @default.
• W2593174977 sameAs 2593174977 @default.
• W2593174977 citedByCount "36" @default.
• W2593174977 countsByYear W25931749772017 @default.
• W2593174977 countsByYear W25931749772018 @default.
• W2593174977 countsByYear W25931749772019 @default.
• W2593174977 countsByYear W25931749772020 @default.
• W2593174977 countsByYear W25931749772021 @default.
• W2593174977 countsByYear W25931749772022 @default.
• W2593174977 countsByYear W25931749772023 @default.
• W2593174977 crossrefType "journal-article" @default.
• W2593174977 hasAuthorship W2593174977A5000629386 @default.
• W2593174977 hasAuthorship W2593174977A5028706102 @default.
• W2593174977 hasAuthorship W2593174977A5039715677 @default.
• W2593174977 hasAuthorship W2593174977A5055546724 @default.
• W2593174977 hasAuthorship W2593174977A5060451719 @default.
• W2593174977 hasAuthorship W2593174977A5064370193 @default.
• W2593174977 hasAuthorship W2593174977A5073190439 @default.
• W2593174977 hasAuthorship W2593174977A5082167284 @default.
• W2593174977 hasAuthorship W2593174977A5085574989 @default.
• W2593174977 hasBestOaLocation W25931749771 @default.
• W2593174977 hasConcept C122325731 @default.
• W2593174977 hasConcept C126322002 @default.
• W2593174977 hasConcept C137923570 @default.
• W2593174977 hasConcept C143121216 @default.
• W2593174977 hasConcept C18903297 @default.
• W2593174977 hasConcept C203014093 @default.
• W2593174977 hasConcept C2777165150 @default.
• W2593174977 hasConcept C2777385719 @default.
• W2593174977 hasConcept C2777695942 @default.
• W2593174977 hasConcept C2779676784 @default.
• W2593174977 hasConcept C2911091166 @default.
• W2593174977 hasConcept C2994496256 @default.
• W2593174977 hasConcept C42062724 @default.
• W2593174977 hasConcept C501593827 @default.
• W2593174977 hasConcept C523546767 @default.
• W2593174977 hasConcept C539455810 @default.
• W2593174977 hasConcept C54355233 @default.
• W2593174977 hasConcept C60644358 @default.
• W2593174977 hasConcept C61716771 @default.
• W2593174977 hasConcept C71924100 @default.
• W2593174977 hasConcept C77077793 @default.
• W2593174977 hasConcept C86803240 @default.

• next