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• W2593199818 startingPage "963" @default.
• W2593199818 abstract "Abstract BACKGROUND The large, expanding literature on biomarkers is characterized by almost ubiquitous significant results, with claims about the potential importance, but few of these discovered biomarkers are used in routine clinical care. CONTENT The pipeline of biomarker development includes several specific stages: discovery, validation, clinical translation, evaluation, implementation (and, in the case of nonutility, deimplementation). Each of these stages can be plagued by problems that cause failures of the overall pipeline. Some problems are nonspecific challenges for all biomedical investigation, while others are specific to the peculiarities of biomarker research. Discovery suffers from poor methods and incomplete and selective reporting. External independent validation is limited. Selection for clinical translation is often shaped by nonrational choices. Evaluation is sparse and the clinical utility of many biomarkers remains unknown. The regulatory environment for biomarkers remains weak and guidelines can reach biased or divergent recommendations. Removing inefficient or even harmful biomarkers that have been entrenched in clinical care can meet with major resistance. SUMMARY The current biomarker pipeline is too prone to failures. Consideration of clinical needs should become a starting point for the development of biomarkers. Improvements can include the use of more stringent methodology, better reporting, larger collaborative studies, careful external independent validation, preregistration, rigorous systematic reviews and umbrella reviews, pivotal randomized trials, and implementation and deimplementation studies. Incentives should be aligned toward delivering useful biomarkers." @default.
• W2593199818 created "2017-03-16" @default.
• W2593199818 creator A5061726857 @default.
• W2593199818 creator A5085949499 @default.
• W2593199818 date "2017-05-01" @default.
• W2593199818 modified "2023-10-13" @default.
• W2593199818 title "Waste, Leaks, and Failures in the Biomarker Pipeline" @default.
• W2593199818 cites W1491223359 @default.
• W2593199818 cites W1544923801 @default.
• W2593199818 cites W1549733517 @default.
• W2593199818 cites W1853602163 @default.
• W2593199818 cites W1963909263 @default.
• W2593199818 cites W1975628667 @default.
• W2593199818 cites W1979891829 @default.
• W2593199818 cites W1987777080 @default.
• W2593199818 cites W1987845650 @default.
• W2593199818 cites W1993198628 @default.
• W2593199818 cites W1994682257 @default.
• W2593199818 cites W1996151477 @default.
• W2593199818 cites W2000213118 @default.
• W2593199818 cites W2001485921 @default.
• W2593199818 cites W2002034360 @default.
• W2593199818 cites W2002555484 @default.
• W2593199818 cites W2004631268 @default.
• W2593199818 cites W2006497939 @default.
• W2593199818 cites W2006920340 @default.
• W2593199818 cites W2017861428 @default.
• W2593199818 cites W2019114939 @default.
• W2593199818 cites W2026756548 @default.
• W2593199818 cites W2028230608 @default.
• W2593199818 cites W2028896946 @default.
• W2593199818 cites W2030731302 @default.
• W2593199818 cites W2033285750 @default.
• W2593199818 cites W2046044306 @default.
• W2593199818 cites W2050416144 @default.
• W2593199818 cites W2052341494 @default.
• W2593199818 cites W2053537559 @default.
• W2593199818 cites W2057178748 @default.
• W2593199818 cites W2060608133 @default.
• W2593199818 cites W2071497144 @default.
• W2593199818 cites W2073618702 @default.
• W2593199818 cites W2077523260 @default.
• W2593199818 cites W2081337065 @default.
• W2593199818 cites W2088363255 @default.
• W2593199818 cites W2093186353 @default.
• W2593199818 cites W2094229819 @default.
• W2593199818 cites W2094713961 @default.
• W2593199818 cites W2095989416 @default.
• W2593199818 cites W2097284317 @default.
• W2593199818 cites W2100741073 @default.
• W2593199818 cites W2104287359 @default.
• W2593199818 cites W2104622393 @default.
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• W2593199818 cites W2106995472 @default.
• W2593199818 cites W2108233388 @default.
• W2593199818 cites W2108420460 @default.
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• W2593199818 cites W2124822309 @default.
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• W2593199818 cites W2130202521 @default.
• W2593199818 cites W2130692776 @default.
• W2593199818 cites W2131865610 @default.
• W2593199818 cites W2133413753 @default.
• W2593199818 cites W2134793522 @default.
• W2593199818 cites W2142846876 @default.
• W2593199818 cites W2147603039 @default.
• W2593199818 cites W2148203699 @default.
• W2593199818 cites W2151619278 @default.
• W2593199818 cites W2153709794 @default.
• W2593199818 cites W2155183384 @default.
• W2593199818 cites W2162217976 @default.
• W2593199818 cites W2165828377 @default.
• W2593199818 cites W2169877598 @default.
• W2593199818 cites W2188214922 @default.
• W2593199818 cites W2194697166 @default.
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• W2593199818 doi "https://doi.org/10.1373/clinchem.2016.254649" @default.
• W2593199818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28270433" @default.
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