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• W2593201475 abstract "It is important to control drug release and detect the distribution of drug molecules before and after release. In this work, [email protected] nanocomposite is prepared for drug delivery, which not only can control drug release by near infrared laser irradiation but also can monitor drug molecules by surface enhanced Raman scattering (SERS) and fluorescence signal during the release process. The [email protected] core/shell nanocomposite prepared by the galvanic replacement reaction (GRR) shows tunable localized surface plasmon resonance (LSPR) absorption peaks from visible to near-infrared region and good biocompatibility. Comparing to pure doxorubicin (DOX) molecules, [email protected] nanocomposite loading DOX exhibit lower cytotoxicity by MTT assay. After loading into [email protected], the fluorescence signal of DOX disappear due to the fluorescence resonance energy transfer from DOX to metals shell. On the contrary, the SERS signal of DOX in [email protected] is obviously increased. Furthermore, the [email protected] nanocomposite shows photothermal conversion ability under resonance laser irradiation. Under 633 nm laser irradiation, the [email protected] nanocomposite loading DOX can release drug molecules for killing cancer cell. Meanwhile, the fluorescence signal from DOX appears after drug release from [email protected], but the SERS signal is not obvious. Therefore, this nanocomposite can provide a platform for photothermal controllable drug release and optical signal targeting for drug molecules." @default.
• W2593201475 created "2017-03-16" @default.
• W2593201475 creator A5024205563 @default.
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• W2593201475 date "2017-06-01" @default.
• W2593201475 modified "2023-10-18" @default.
• W2593201475 title "SERS-active liposome@Ag/Au nanocomposite for NIR light-driven drug release" @default.
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• W2593201475 doi "https://doi.org/10.1016/j.colsurfb.2017.03.016" @default.
• W2593201475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28334692" @default.
• W2593201475 hasPublicationYear "2017" @default.
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