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- W2593217217 abstract "The use of pre-prepared diaminodiacids has been established as an effective approach for the chemical synthesis of peptide disulfide bond mimics. A technical problem often encountered in the implementation of the diaminodiacids strategy is the use of heavy metal reagents to remove the side-chain protecting groups. In the present work, we reported the development of diaminodiacid that carry 4-(N-[1-(4,4-dimethyl-2,6-dioxocyclo-hexylidene)-3-methylbutyl]amino)benzyl (Dmab) and 1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl (ivDde) protecting groups. This pair of protecting groups can be readily removed by mild hydrazinolysis during the solid-phase synthesis on resin. We demonstrated the use of Dmab/ivDde protected diaminodiacids in the successful synthesis of a disulfide surrogate of oxytocin." @default.
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- W2593217217 date "2017-04-01" @default.
- W2593217217 modified "2023-10-16" @default.
- W2593217217 title "Dmab/ivDde protected diaminodiacids for solid-phase synthesis of peptide disulfide-bond mimics" @default.
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- W2593217217 doi "https://doi.org/10.1016/j.tetlet.2017.03.024" @default.
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