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• W2593236478 endingPage "735" @default.
• W2593236478 startingPage "723" @default.
• W2593236478 abstract "Genes belonging to neuroplasticity, monoamine, circadian rhythm, and transcription factor pathways were investigated as modulators of antidepressant efficacy. The present study aimed (1) to replicate previous findings in an independent sample with treatment-resistant depression (TRD), and (2) to perform a pathway analysis to investigate the possible molecular mechanisms involved. 220 patients with major depressive disorder who were non-responders to a previous antidepressant were treated with venlafaxine for 4–6 weeks and in case of non-response with escitalopram for 4–6 weeks. Symptoms were assessed using the Montgomery Asberg Depression Rating Scale. The phenotypes were response and remission to venlafaxine, non-response (TRDA) and non-remission (TRDB) to neither venlafaxine nor escitalopram. 50 tag SNPs in 14 genes belonging to the pathways of interest were tested for association with phenotypes. Molecular pathways (KEGG database) that included one or more of the genes associated with the phenotypes were investigated also in the STAR*D sample. The associations between ZNF804A rs7603001 and response, CREB1 rs2254137 and remission were replicated, as well as CHL1 rs2133402 and lower risk of TRD. Other CHL1 SNPs were potential predictors of TRD (rs1516340, rs2272522, rs1516338, rs2133402). The MAPK1 rs6928 SNP was consistently associated with all the phenotypes. The protein processing in endoplasmic reticulum pathway (hsa04141) was the best pathway that may explain the mechanisms of MAPK1 involvement in antidepressant response. Signals in genes previously associated with antidepressant efficacy were confirmed for CREB1, ZNF804A and CHL1. These genes play pivotal roles in synaptic plasticity, neural activity and connectivity." @default.
• W2593236478 created "2017-03-16" @default.
• W2593236478 creator A5002162783 @default.
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• W2593236478 date "2017-03-04" @default.
• W2593236478 modified "2023-10-18" @default.
• W2593236478 title "Neuroplasticity and second messenger pathways in antidepressant efficacy: pharmacogenetic results from a prospective trial investigating treatment resistance" @default.
• W2593236478 cites W146502225 @default.
• W2593236478 cites W1530984097 @default.
• W2593236478 cites W1581543871 @default.
• W2593236478 cites W1660095449 @default.
• W2593236478 cites W17682570 @default.
• W2593236478 cites W1812789581 @default.
• W2593236478 cites W1825797577 @default.
• W2593236478 cites W1965171314 @default.
• W2593236478 cites W1965331012 @default.
• W2593236478 cites W1966688595 @default.
• W2593236478 cites W1970506215 @default.
• W2593236478 cites W1970821395 @default.
• W2593236478 cites W1972182605 @default.
• W2593236478 cites W1979848549 @default.
• W2593236478 cites W1980799173 @default.
• W2593236478 cites W1981884688 @default.
• W2593236478 cites W1982313674 @default.
• W2593236478 cites W1991381469 @default.
• W2593236478 cites W2000209446 @default.
• W2593236478 cites W2001279805 @default.
• W2593236478 cites W2004019168 @default.
• W2593236478 cites W2006462748 @default.
• W2593236478 cites W2007506824 @default.
• W2593236478 cites W2008971294 @default.
• W2593236478 cites W2011039340 @default.
• W2593236478 cites W2011814168 @default.
• W2593236478 cites W2017727557 @default.
• W2593236478 cites W2018084397 @default.
• W2593236478 cites W2019808168 @default.
• W2593236478 cites W2019878424 @default.
• W2593236478 cites W2028370025 @default.
• W2593236478 cites W2030525076 @default.
• W2593236478 cites W2030935953 @default.
• W2593236478 cites W2033132892 @default.
• W2593236478 cites W2034424952 @default.
• W2593236478 cites W2039316644 @default.
• W2593236478 cites W2040140774 @default.
• W2593236478 cites W2045449496 @default.
• W2593236478 cites W2046928718 @default.
• W2593236478 cites W2054247262 @default.
• W2593236478 cites W2056261919 @default.
• W2593236478 cites W2057828422 @default.
• W2593236478 cites W2059483509 @default.
• W2593236478 cites W2059676567 @default.
• W2593236478 cites W2062251431 @default.
• W2593236478 cites W2067604141 @default.
• W2593236478 cites W2068936495 @default.
• W2593236478 cites W2070869160 @default.
• W2593236478 cites W2077247278 @default.
• W2593236478 cites W2078151387 @default.
• W2593236478 cites W2079111763 @default.
• W2593236478 cites W2087484885 @default.
• W2593236478 cites W2090313686 @default.
• W2593236478 cites W2090504463 @default.
• W2593236478 cites W2095852687 @default.
• W2593236478 cites W2096927391 @default.
• W2593236478 cites W2101463726 @default.
• W2593236478 cites W2103423058 @default.
• W2593236478 cites W2103587403 @default.
• W2593236478 cites W2104446705 @default.
• W2593236478 cites W2115600578 @default.
• W2593236478 cites W2118977349 @default.
• W2593236478 cites W2125904354 @default.
• W2593236478 cites W2126835057 @default.
• W2593236478 cites W2130355017 @default.
• W2593236478 cites W2130417276 @default.
• W2593236478 cites W2135612460 @default.
• W2593236478 cites W2140787893 @default.
• W2593236478 cites W2142133137 @default.
• W2593236478 cites W2142478420 @default.
• W2593236478 cites W2143742981 @default.
• W2593236478 cites W2146222555 @default.
• W2593236478 cites W2148424874 @default.
• W2593236478 cites W2149375666 @default.
• W2593236478 cites W2149402043 @default.
• W2593236478 cites W2152756396 @default.
• W2593236478 cites W2158321076 @default.
• W2593236478 cites W2163419977 @default.
• W2593236478 cites W4211258630 @default.

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