FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2593254632> ?p ?o ?g. }

• W2593254632 endingPage "96" @default.
• W2593254632 startingPage "88" @default.
• W2593254632 abstract "Interleukin 10 (IL-10) is an immunomodulatory cytokine that plays a central role in the pathogenesis of autoimmune diseases. Different studies consistently show increased IL-10 serum levels in rheumatoid arthritis (RA) and it appears to be caused by genetic variants. Three polymorphisms situated at positions −1082, −819 and −592 of IL10 gene and its major haplotypes have been associated with regulating IL10 promoter activity. In this study, we evaluated whether IL10 haplotypes are associated with mRNA expression and IL-10 serum levels as well as susceptibility to RA in a Western Mexican population. A total of 240 RA patients and 240 control subjects (CS) were included. Genotyping of IL10 polymorphisms was performed by PCR and PCR-RFLP, respectively. IL10 mRNA expression was determined by real-time PCR and IL-10 serum levels were measured using an ELISA kit. IL10 mRNA expression was 50-fold higher in RA patients than CS (p < 0.001), while IL-10 serum levels did not show differences between groups. However, high IL-10 serum levels were positively related to a higher seropositivity for rheumatoid factor (FR) and anti-CCP antibodies (p < 0.05). No significant differences between the distribution of haplotype frequencies were observed between both study groups, but GCC haplotype was associated with higher IL-10 serum levels compared with the ACC and ATA haplotypes in RA patients (p < 0.05). In addition, patients carrying ATA and GCC haplotypes showed higher mRNA expression than ACC (5.4-fold and 8.8-fold, respectively) and surprisingly, this trend was reversed in the controls, although it was not significant. In conclusion, our findings suggest that IL10 (GCC, ACC, and ATA) haplotypes may not be a susceptibility marker for RA in a population from Western Mexico. Nevertheless, independently of the presence of these variants, there is an aberrant overexpression of IL10 gene in RA, and it may play an important role in the pathogenesis of RA." @default.
• W2593254632 created "2017-03-16" @default.
• W2593254632 creator A5006606244 @default.
• W2593254632 creator A5028521592 @default.
• W2593254632 creator A5030273001 @default.
• W2593254632 creator A5031887164 @default.
• W2593254632 creator A5038069324 @default.
• W2593254632 creator A5043726424 @default.
• W2593254632 creator A5054539295 @default.
• W2593254632 creator A5078418298 @default.
• W2593254632 creator A5082688687 @default.
• W2593254632 creator A5088168825 @default.
• W2593254632 date "2017-07-01" @default.
• W2593254632 modified "2023-10-17" @default.
• W2593254632 title "Aberrant expression of interleukin-10 in rheumatoid arthritis: Relationship with IL10 haplotypes and autoantibodies" @default.
• W2593254632 cites W1209106218 @default.
• W2593254632 cites W1511861289 @default.
• W2593254632 cites W1586387504 @default.
• W2593254632 cites W1966755507 @default.
• W2593254632 cites W1973919963 @default.
• W2593254632 cites W1976741643 @default.
• W2593254632 cites W1988280501 @default.
• W2593254632 cites W1989071494 @default.
• W2593254632 cites W1996922800 @default.
• W2593254632 cites W2001743141 @default.
• W2593254632 cites W2004911892 @default.
• W2593254632 cites W2007545799 @default.
• W2593254632 cites W2016937109 @default.
• W2593254632 cites W2017749666 @default.
• W2593254632 cites W2025222181 @default.
• W2593254632 cites W2034032711 @default.
• W2593254632 cites W2034614509 @default.
• W2593254632 cites W2036144540 @default.
• W2593254632 cites W2036455715 @default.
• W2593254632 cites W2036674118 @default.
• W2593254632 cites W2037765896 @default.
• W2593254632 cites W2042474497 @default.
• W2593254632 cites W2047543986 @default.
• W2593254632 cites W2053921780 @default.
• W2593254632 cites W2056364365 @default.
• W2593254632 cites W2069309860 @default.
• W2593254632 cites W2077853537 @default.
• W2593254632 cites W2083993552 @default.
• W2593254632 cites W2086751610 @default.
• W2593254632 cites W2094739664 @default.
• W2593254632 cites W2097155839 @default.
• W2593254632 cites W2099066165 @default.
• W2593254632 cites W2099759573 @default.
• W2593254632 cites W2106684817 @default.
• W2593254632 cites W2107277218 @default.
• W2593254632 cites W2110177517 @default.
• W2593254632 cites W2117931579 @default.
• W2593254632 cites W2118094114 @default.
• W2593254632 cites W2128952811 @default.
• W2593254632 cites W2133632043 @default.
• W2593254632 cites W2136709048 @default.
• W2593254632 cites W2141072599 @default.
• W2593254632 cites W2156118511 @default.
• W2593254632 cites W2159487337 @default.
• W2593254632 cites W2161074777 @default.
• W2593254632 cites W2164979183 @default.
• W2593254632 cites W2166044756 @default.
• W2593254632 cites W2587817005 @default.
• W2593254632 cites W4294216491 @default.
• W2593254632 cites W612883663 @default.
• W2593254632 doi "https://doi.org/10.1016/j.cyto.2017.02.022" @default.
• W2593254632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28254559" @default.
• W2593254632 hasPublicationYear "2017" @default.
• W2593254632 type Work @default.
• W2593254632 sameAs 2593254632 @default.
• W2593254632 citedByCount "23" @default.
• W2593254632 countsByYear W25932546322017 @default.
• W2593254632 countsByYear W25932546322018 @default.
• W2593254632 countsByYear W25932546322019 @default.
• W2593254632 countsByYear W25932546322020 @default.
• W2593254632 countsByYear W25932546322021 @default.
• W2593254632 countsByYear W25932546322022 @default.
• W2593254632 countsByYear W25932546322023 @default.
• W2593254632 crossrefType "journal-article" @default.
• W2593254632 hasAuthorship W2593254632A5006606244 @default.
• W2593254632 hasAuthorship W2593254632A5028521592 @default.
• W2593254632 hasAuthorship W2593254632A5030273001 @default.
• W2593254632 hasAuthorship W2593254632A5031887164 @default.
• W2593254632 hasAuthorship W2593254632A5038069324 @default.
• W2593254632 hasAuthorship W2593254632A5043726424 @default.
• W2593254632 hasAuthorship W2593254632A5054539295 @default.
• W2593254632 hasAuthorship W2593254632A5078418298 @default.
• W2593254632 hasAuthorship W2593254632A5082688687 @default.
• W2593254632 hasAuthorship W2593254632A5088168825 @default.
• W2593254632 hasConcept C104317684 @default.
• W2593254632 hasConcept C126322002 @default.
• W2593254632 hasConcept C135763542 @default.
• W2593254632 hasConcept C159654299 @default.
• W2593254632 hasConcept C163764329 @default.
• W2593254632 hasConcept C187316574 @default.
• W2593254632 hasConcept C197754878 @default.
• W2593254632 hasConcept C203014093 @default.
• W2593254632 hasConcept C2777575956 @default.

• next