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• W2593257494 abstract "We have designed a polymer micelles based on Pluronic P 123 and Polyethyleneimine 600 (termed as P 123 P 600 ). Upon critical micelle concentration the P 123 P 600 unimer formed micelles in water. These micelles not only could simultaneously delivery hydrophobic anticancer drug paclitaxel (PTX) to cancer cells but also could deplete ATP and inhibit P-gp expression in MDR cells. In vitro researches demonstrated that these micelles showed the excellent biocompatibility, high drug loading efficiency, stably controlled releasing behavior, enhanced cellular up-take and improved serum stability. In vivo studies demonstrated that the PTX loaded micelles induced tumor cell apoptosis and inhibited the growth of tumor to overcome drug resistance through a synergistic effect. All these findings suggested that P 123 P 600 for delivery of anticarcinogen provided a promising strategy for reversal of MDR in cancer treatment." @default.
• W2593257494 created "2017-03-16" @default.
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• W2593257494 date "2017-03-01" @default.
• W2593257494 modified "2023-09-27" @default.
• W2593257494 title "Pluronic-PEI Micelles Reverse Multidrug Resistance by Depleting ATP and Inhibiting P-Glycoprotein for Colon Cancer Therapy" @default.
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• W2593257494 doi "https://doi.org/10.4028/www.scientific.net/msf.886.111" @default.
• W2593257494 hasPublicationYear "2017" @default.
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