FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2593263211> ?p ?o ?g. }

• W2593263211 abstract "Histamine is an aminergic neurotransmitter, which regulates wakefulness, arousal and attention in the central nervous system. Histamine receptors have been the target of efforts to develop pro-cognitive drugs to treat disorders such as Alzheimer's disease and schizophrenia. Cognitive functions including attention are closely associated with gamma oscillations, a rhythmical electrical activity pattern in the 30-80 Hz range, which depends on the synchronized activity of excitatory pyramidal cells and inhibitory fast-spiking interneurons. We set out to explore whether histamine has a role in promoting gamma oscillations in the hippocampus. Using in-situ hybridization we demonstrate that histamine receptor subtypes 1, 2 and 3 are expressed in stratum pyramidale of area CA3 in rats. We show that both pyramidal cells and fast-spiking interneurons depolarize and increase action potential firing in response to histamine in vitro. The activation of histamine receptors generates dose-dependent, transient gamma oscillations in area CA3 of the hippocampus - the locus of the gamma rhythm generator. We also demonstrate that this histamine effect is independent of muscarinic receptors. Using specific antagonists we provide evidence that histamine gamma rhythmogenesis specifically depends on the H1 receptor. Histamine also depolarized both pyramidal cells and fast-spiking interneurons and increased membrane resistance in pyramidal cells. The increased membrane resistance is potentially mediated by the inhibition of potassium channels because application of the KCNQ channel opener ICA110381 abolished the oscillations. Taken together our data demonstrate a novel and physiological mechanism for generating gamma oscillations in hippocampus and suggest a role for KCNQ channels in this cognition-relevant brain activity." @default.
• W2593263211 created "2017-03-16" @default.
• W2593263211 creator A5051941809 @default.
• W2593263211 creator A5061649366 @default.
• W2593263211 creator A5066507216 @default.
• W2593263211 creator A5087013194 @default.
• W2593263211 date "2017-05-01" @default.
• W2593263211 modified "2023-10-03" @default.
• W2593263211 title "Histamine induces KCNQ channel-dependent gamma oscillations in rat hippocampus via activation of the H1 receptor" @default.
• W2593263211 cites W1531455680 @default.
• W2593263211 cites W1573714023 @default.
• W2593263211 cites W1664200544 @default.
• W2593263211 cites W1736719008 @default.
• W2593263211 cites W1854755157 @default.
• W2593263211 cites W1965127680 @default.
• W2593263211 cites W1965414505 @default.
• W2593263211 cites W1968385825 @default.
• W2593263211 cites W1971542322 @default.
• W2593263211 cites W1973783515 @default.
• W2593263211 cites W1981761337 @default.
• W2593263211 cites W1990845627 @default.
• W2593263211 cites W1992813376 @default.
• W2593263211 cites W2011467935 @default.
• W2593263211 cites W2017445565 @default.
• W2593263211 cites W2021780530 @default.
• W2593263211 cites W2022628868 @default.
• W2593263211 cites W2028191749 @default.
• W2593263211 cites W2041244640 @default.
• W2593263211 cites W2041359982 @default.
• W2593263211 cites W2044712116 @default.
• W2593263211 cites W2045165394 @default.
• W2593263211 cites W2047066043 @default.
• W2593263211 cites W2047347093 @default.
• W2593263211 cites W2048393756 @default.
• W2593263211 cites W2054762913 @default.
• W2593263211 cites W2057002584 @default.
• W2593263211 cites W2059510192 @default.
• W2593263211 cites W2062032687 @default.
• W2593263211 cites W2063451981 @default.
• W2593263211 cites W2071418267 @default.
• W2593263211 cites W2074475076 @default.
• W2593263211 cites W2075316492 @default.
• W2593263211 cites W2083276108 @default.
• W2593263211 cites W2085350184 @default.
• W2593263211 cites W2094211651 @default.
• W2593263211 cites W2101793659 @default.
• W2593263211 cites W2104286491 @default.
• W2593263211 cites W2104481975 @default.
• W2593263211 cites W2114192904 @default.
• W2593263211 cites W2122008829 @default.
• W2593263211 cites W2123035658 @default.
• W2593263211 cites W2134726538 @default.
• W2593263211 cites W2136592011 @default.
• W2593263211 cites W2136860890 @default.
• W2593263211 cites W2148261053 @default.
• W2593263211 cites W2149561999 @default.
• W2593263211 cites W2157787057 @default.
• W2593263211 cites W2162013747 @default.
• W2593263211 cites W2166214108 @default.
• W2593263211 cites W2170814877 @default.
• W2593263211 doi "https://doi.org/10.1016/j.neuropharm.2017.03.003" @default.
• W2593263211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28274820" @default.
• W2593263211 hasPublicationYear "2017" @default.
• W2593263211 type Work @default.
• W2593263211 sameAs 2593263211 @default.
• W2593263211 citedByCount "7" @default.
• W2593263211 countsByYear W25932632112018 @default.
• W2593263211 countsByYear W25932632112021 @default.
• W2593263211 countsByYear W25932632112022 @default.
• W2593263211 crossrefType "journal-article" @default.
• W2593263211 hasAuthorship W2593263211A5051941809 @default.
• W2593263211 hasAuthorship W2593263211A5061649366 @default.
• W2593263211 hasAuthorship W2593263211A5066507216 @default.
• W2593263211 hasAuthorship W2593263211A5087013194 @default.
• W2593263211 hasConcept C10335311 @default.
• W2593263211 hasConcept C1122143 @default.
• W2593263211 hasConcept C112592302 @default.
• W2593263211 hasConcept C12554922 @default.
• W2593263211 hasConcept C134018914 @default.
• W2593263211 hasConcept C148762608 @default.
• W2593263211 hasConcept C159545944 @default.
• W2593263211 hasConcept C169760540 @default.
• W2593263211 hasConcept C170493617 @default.
• W2593263211 hasConcept C17077164 @default.
• W2593263211 hasConcept C185592680 @default.
• W2593263211 hasConcept C2776885963 @default.
• W2593263211 hasConcept C2778437258 @default.
• W2593263211 hasConcept C2781161787 @default.
• W2593263211 hasConcept C4141045 @default.
• W2593263211 hasConcept C55493867 @default.
• W2593263211 hasConcept C63180777 @default.
• W2593263211 hasConcept C86803240 @default.
• W2593263211 hasConceptScore W2593263211C10335311 @default.
• W2593263211 hasConceptScore W2593263211C1122143 @default.
• W2593263211 hasConceptScore W2593263211C112592302 @default.
• W2593263211 hasConceptScore W2593263211C12554922 @default.
• W2593263211 hasConceptScore W2593263211C134018914 @default.
• W2593263211 hasConceptScore W2593263211C148762608 @default.
• W2593263211 hasConceptScore W2593263211C159545944 @default.
• W2593263211 hasConceptScore W2593263211C169760540 @default.

• next