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- W2593277112 abstract "High individuality, large complexity and limited understanding of the mechanisms underlying human intestinal microbiome function remain the major challenges for designing beneficial modulation strategies. Exemplified by the analysis of intestinal bacteria in a thousand Western adults, we discuss key concepts of the human intestinal microbiome landscape, i.e. the compositional and functional 'core', the presence of community types and the existence of alternative stable states. Genomic investigation of core taxa revealed functional redundancy, which is expected to stabilize the ecosystem, as well as taxa with specialized functions that have the potential to shape the microbiome landscape. The contrast between Prevotella- and Bacteroides-dominated systems has been well described. However, less known is the effect of not so abundant bacteria, for example, Dialister spp. that have been proposed to exhibit distinct bistable dynamics. Studies employing time-series analysis have highlighted the dynamical variation in the microbiome landscape with and without the effect of defined perturbations, such as the use of antibiotics or dietary changes. We incorporate ecosystem-level observations of the human intestinal microbiota and its keystone species to suggest avenues for designing microbiome modulation strategies to improve host health." @default.
- W2593277112 created "2017-03-16" @default.
- W2593277112 creator A5014776360 @default.
- W2593277112 creator A5054572740 @default.
- W2593277112 creator A5068718584 @default.
- W2593277112 creator A5070695107 @default.
- W2593277112 creator A5082648063 @default.
- W2593277112 date "2017-02-09" @default.
- W2593277112 modified "2023-10-17" @default.
- W2593277112 title "Intestinal microbiome landscaping: insight in community assemblage and implications for microbial modulation strategies" @default.
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