Matches in SemOpenAlex for { <https://semopenalex.org/work/W2593293144> ?p ?o ?g. }
- W2593293144 endingPage "13" @default.
- W2593293144 startingPage "1" @default.
- W2593293144 abstract "Deregulated angiogenesis plays a central role in the development and metastasis of solid cancers. Tumor vasculature expressing a variety of biomarkers offers some novel therapeutic options which can be selectively targeted with anti-angiogenic agents without significantly affecting the normal vasculature. However, anti-angiogenic agents currently available commercially (synthetic compounds and humanized monoclonal antibodies) have been designed to target specific molecular markers within the cell signalling networks in addition to being expensive as well as toxic. Therefore, it is highly desirable to search for new therapeutic moieties which can simultaneously treat multiple aberrant pathways yet being less toxic and inexpensive. Several studies have highlighted that medicinal plants either as crude extracts or as pure isolated compounds can meet these criteria. The unique combination of different classes of phytochemicals present in plant extracts have been shown simultaneously to target multiple abnormal pathways in the tumor angiogenic cascade thus arresting growth of tumor cells at various stages. In addition, these phytochemicals have health promoting benefits making them ideal candidates to be pursued for drug development. The current review provides an update on the broad spectrum anti-angiogenic activities of different classes of phytochemicals present in the medicinal plants. Although pre-clinical studies have shown promising results, further studies are required to explore the in-depth molecular mechanisms responsible for the observed pharmacological activities and to test the efficacy of isolated compounds or standardised extracts in properly designed experiments. In addition, long term toxicity studies and data on interaction with other drugs are also required to establish the safety profile of extracts before the commencement of clinical trials." @default.
- W2593293144 created "2017-03-16" @default.
- W2593293144 creator A5004162511 @default.
- W2593293144 creator A5004777713 @default.
- W2593293144 creator A5006843885 @default.
- W2593293144 creator A5020964360 @default.
- W2593293144 creator A5074326324 @default.
- W2593293144 creator A5079325383 @default.
- W2593293144 date "2017-09-01" @default.
- W2593293144 modified "2023-09-27" @default.
- W2593293144 title "Broad spectrum targeting of tumor vasculature by medicinal plants: An updated review" @default.
- W2593293144 cites W1518976036 @default.
- W2593293144 cites W1567029837 @default.
- W2593293144 cites W1945464539 @default.
- W2593293144 cites W1965694039 @default.
- W2593293144 cites W1970287932 @default.
- W2593293144 cites W1971639991 @default.
- W2593293144 cites W1973186585 @default.
- W2593293144 cites W1977757200 @default.
- W2593293144 cites W1978295110 @default.
- W2593293144 cites W1980102481 @default.
- W2593293144 cites W1980236411 @default.
- W2593293144 cites W1982103277 @default.
- W2593293144 cites W1983029081 @default.
- W2593293144 cites W1984667291 @default.
- W2593293144 cites W1989600682 @default.
- W2593293144 cites W1993084580 @default.
- W2593293144 cites W1993660328 @default.
- W2593293144 cites W1995760091 @default.
- W2593293144 cites W1995865662 @default.
- W2593293144 cites W1996678055 @default.
- W2593293144 cites W1996913481 @default.
- W2593293144 cites W1997862837 @default.
- W2593293144 cites W1999607568 @default.
- W2593293144 cites W2000834839 @default.
- W2593293144 cites W2001641583 @default.
- W2593293144 cites W2001912065 @default.
- W2593293144 cites W2002809636 @default.
- W2593293144 cites W2005444068 @default.
- W2593293144 cites W2006697833 @default.
- W2593293144 cites W2006937382 @default.
- W2593293144 cites W2008037340 @default.
- W2593293144 cites W2008656186 @default.
- W2593293144 cites W2012611518 @default.
- W2593293144 cites W2014144838 @default.
- W2593293144 cites W2014168393 @default.
- W2593293144 cites W2017107262 @default.
- W2593293144 cites W2019020199 @default.
- W2593293144 cites W2020361205 @default.
- W2593293144 cites W2020436413 @default.
- W2593293144 cites W2021222438 @default.
- W2593293144 cites W2028286877 @default.
- W2593293144 cites W2030070877 @default.
- W2593293144 cites W2030475899 @default.
- W2593293144 cites W2030580035 @default.
- W2593293144 cites W2030670932 @default.
- W2593293144 cites W2030750084 @default.
- W2593293144 cites W2032337032 @default.
- W2593293144 cites W2033421040 @default.
- W2593293144 cites W2037257887 @default.
- W2593293144 cites W2038495453 @default.
- W2593293144 cites W2038697597 @default.
- W2593293144 cites W2041365221 @default.
- W2593293144 cites W2043268707 @default.
- W2593293144 cites W2044623277 @default.
- W2593293144 cites W2047074986 @default.
- W2593293144 cites W2048775582 @default.
- W2593293144 cites W2049782403 @default.
- W2593293144 cites W2050555289 @default.
- W2593293144 cites W2051124828 @default.
- W2593293144 cites W2051649534 @default.
- W2593293144 cites W2054206661 @default.
- W2593293144 cites W2055256924 @default.
- W2593293144 cites W2059199112 @default.
- W2593293144 cites W2063299574 @default.
- W2593293144 cites W2066365279 @default.
- W2593293144 cites W2067856799 @default.
- W2593293144 cites W2069755388 @default.
- W2593293144 cites W2070555377 @default.
- W2593293144 cites W2073827396 @default.
- W2593293144 cites W2075271169 @default.
- W2593293144 cites W2075935674 @default.
- W2593293144 cites W2077007598 @default.
- W2593293144 cites W2078831149 @default.
- W2593293144 cites W2079916310 @default.
- W2593293144 cites W2086850865 @default.
- W2593293144 cites W2088673175 @default.
- W2593293144 cites W2089303046 @default.
- W2593293144 cites W2089490940 @default.
- W2593293144 cites W2090051063 @default.
- W2593293144 cites W2090431204 @default.
- W2593293144 cites W2093412095 @default.
- W2593293144 cites W2093631131 @default.
- W2593293144 cites W2096474547 @default.
- W2593293144 cites W2105187139 @default.
- W2593293144 cites W2110907574 @default.
- W2593293144 cites W2113470533 @default.
- W2593293144 cites W2115099477 @default.