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- W2593304855 abstract "Objective: The aim of our study was to formulate and evaluate the liposomal carrier system for the local treatmentfor mixed vaginal infections. The combination of voriconazole and metronidazole were selected as model drugs formixed vaginal infections.Methods:Multi lamellar liposomescomposed phosphatidylcholine and cholesterol alongwith combination of drugs was prepared by the thin film hydration method. The prepared liposome werecharacterized for fourier transform infrared, size distribution, entrapment efficiency, in vitrorelease study insimulated vaginal fluid and stability studies.The liposomes were loaded to carbopol gel. The liposomes loadedcarbopol gels were evaluated for in vitrodrugs release study and compared with control gel. Results: FTIR studyindicated that there is no significant chemical interaction between the components.The cumulative percentreleasefrom liposomal gels FL1 was found to be 69.90% for metronidazole and 56.02 % for voriconazole.In vitrorelease studies of liposomes incorporated in the carbopol gel have shown a prolonged release of entrappedmetronidazole and voriconazole compared to control gel. Stability studies showed that the vesicles were stableinrefrigerated temperature (4 °C) for 60 days without significant differences in drug entrapment.Conclusion:Fromthe results it was evident that the liposomes are capable to efficiently deliver entrapped drug for the extended periodof time within a bioadhesive gel. The bioadhesive gel in combination of these two drugs is effective in more than onetype of vaginal infections." @default.
- W2593304855 created "2017-03-16" @default.
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- W2593304855 date "2015-01-01" @default.
- W2593304855 modified "2023-09-23" @default.
- W2593304855 title "Formulation and evaluation of liposomes in carbopol gels for mixed vaginalinfections" @default.
- W2593304855 hasPublicationYear "2015" @default.
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