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- W2593333189 abstract "Background Severe acute cellular rejection (ACR) occurs frequently after intestinal transplantation (ITx). Aim To evaluate the outcomes and the risk factors for graft failure and mortality in patients with severe ACR after ITx. Methods Retrospective study evaluating all ITx recipients who developed severe ACR between 01/2000 and 07/2014. Demographic and histologic data were reviewed. Results 20/126 (15.9%) ITx recipients developed severe ACR. Of these 20 episodes, 13 were in adults (median age: 47.1). The median (IQR) time from ITx to severe ACR was 206.5 (849) days. All patients received intravenous methylprednisolone and increased doses of tacrolimus. Sixteen (80%) patients did not respond to initial treatment and required thymoglobulin administration. Moreover, 11 (55%) patients required additional immunosuppressive medications. Six (30%) patients required graft enterectomy. Complications related to ACR treatment were the following: 10 (50%) patients developed bacterial infections, four (20%) patients developed cytomegalovirus infection and four (20%) patients developed post-transplant lymphoproliferative disease. At the end of follow-up, only 3/20 (15%) were alive with a functional allograft. The median patient survival time after diagnosis of severe ACR was 400 days (95% CI: 234.0-2613.0). Conclusions Severe ACR episodes are associated with high rates of graft loss and complications related to treatment." @default.
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- W2593333189 date "2017-03-31" @default.
- W2593333189 modified "2023-10-02" @default.
- W2593333189 title "Severe acute cellular rejection after intestinal transplantation is associated with poor patient and graft survival" @default.
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- W2593333189 doi "https://doi.org/10.1111/ctr.12956" @default.
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