Matches in SemOpenAlex for { <https://semopenalex.org/work/W2593353214> ?p ?o ?g. }
- W2593353214 abstract "Abstract Despite promising therapeutic avenues, there is currently no effective treatment for Duchenne muscular dystrophy (DMD), a lethal monogenic disorder caused by the loss of the large cytoskeletal protein, dystrophin. A highly promising approach to therapy, applicable to all DMD patients irrespective to their genetic defect, is to modulate utrophin, a functional paralogue of dystrophin, able to compensate for the primary defects of DMD restoring sarcolemmal stability. One of the major difficulties in assessing the effectiveness of therapeutic strategies is to define appropriate outcome measures. In the present study, we utilised an aptamer based proteomics approach to profile 1,310 proteins in plasma of wild-type, mdx and Fiona ( mdx overexpressing utrophin) mice. Comparison of the C57 and mdx sera revealed 83 proteins with statistically significant >2 fold changes in dystrophic serum abundance. A large majority of previously described biomarkers (ANP32B, THBS4, CAMK2A/B/D, CYCS, CAPNI) were normalised towards wild-type levels in Fiona animals. This work also identified potential mdx markers specific to increased utrophin (DUS3, TPI1) and highlights novel mdx biomarkers (GITR, MYBPC1, HSP60, SIRT2, SMAD3, CNTN1). We define a panel of putative protein mdx biomarkers to evaluate utrophin based strategies which may help to accelerate their translation to the clinic." @default.
- W2593353214 created "2017-03-16" @default.
- W2593353214 creator A5004477044 @default.
- W2593353214 creator A5005383467 @default.
- W2593353214 creator A5036949637 @default.
- W2593353214 creator A5044674483 @default.
- W2593353214 creator A5062583187 @default.
- W2593353214 creator A5072251510 @default.
- W2593353214 creator A5077583490 @default.
- W2593353214 creator A5078292123 @default.
- W2593353214 date "2017-03-02" @default.
- W2593353214 modified "2023-09-23" @default.
- W2593353214 title "Identification of serum protein biomarkers for utrophin based DMD therapy" @default.
- W2593353214 cites W1508659364 @default.
- W2593353214 cites W1524530894 @default.
- W2593353214 cites W1558196299 @default.
- W2593353214 cites W1573786554 @default.
- W2593353214 cites W1768519351 @default.
- W2593353214 cites W1935523855 @default.
- W2593353214 cites W1966229842 @default.
- W2593353214 cites W1968854849 @default.
- W2593353214 cites W1972137179 @default.
- W2593353214 cites W1972671890 @default.
- W2593353214 cites W1973980541 @default.
- W2593353214 cites W1989812175 @default.
- W2593353214 cites W1999351569 @default.
- W2593353214 cites W2003377627 @default.
- W2593353214 cites W2003922674 @default.
- W2593353214 cites W2018722071 @default.
- W2593353214 cites W2023375902 @default.
- W2593353214 cites W2023972061 @default.
- W2593353214 cites W2025669016 @default.
- W2593353214 cites W2026728314 @default.
- W2593353214 cites W2032902046 @default.
- W2593353214 cites W2033746426 @default.
- W2593353214 cites W2035975703 @default.
- W2593353214 cites W2038546974 @default.
- W2593353214 cites W2038839376 @default.
- W2593353214 cites W2039035739 @default.
- W2593353214 cites W2042996461 @default.
- W2593353214 cites W2045209184 @default.
- W2593353214 cites W2050388013 @default.
- W2593353214 cites W2053079324 @default.
- W2593353214 cites W2054963293 @default.
- W2593353214 cites W2058567590 @default.
- W2593353214 cites W2064759457 @default.
- W2593353214 cites W2067581129 @default.
- W2593353214 cites W2071452602 @default.
- W2593353214 cites W2072775800 @default.
- W2593353214 cites W2074248426 @default.
- W2593353214 cites W2075184118 @default.
- W2593353214 cites W2078680005 @default.
- W2593353214 cites W2083700023 @default.
- W2593353214 cites W2084373725 @default.
- W2593353214 cites W2084842518 @default.
- W2593353214 cites W2090177793 @default.
- W2593353214 cites W2091212285 @default.
- W2593353214 cites W2101455790 @default.
- W2593353214 cites W2104142451 @default.
- W2593353214 cites W2105921617 @default.
- W2593353214 cites W2113949094 @default.
- W2593353214 cites W2114790187 @default.
- W2593353214 cites W2116484895 @default.
- W2593353214 cites W2123933559 @default.
- W2593353214 cites W2141619720 @default.
- W2593353214 cites W2141695132 @default.
- W2593353214 cites W2142261920 @default.
- W2593353214 cites W2142539012 @default.
- W2593353214 cites W2144034294 @default.
- W2593353214 cites W2146367762 @default.
- W2593353214 cites W2147931742 @default.
- W2593353214 cites W2151214389 @default.
- W2593353214 cites W2153766856 @default.
- W2593353214 cites W2155995223 @default.
- W2593353214 cites W2161203480 @default.
- W2593353214 cites W2163924091 @default.
- W2593353214 cites W2165368743 @default.
- W2593353214 cites W2166810075 @default.
- W2593353214 cites W2176451438 @default.
- W2593353214 cites W2230478798 @default.
- W2593353214 cites W2234725241 @default.
- W2593353214 cites W2301243053 @default.
- W2593353214 cites W2317678555 @default.
- W2593353214 cites W2328111136 @default.
- W2593353214 cites W2337696333 @default.
- W2593353214 cites W2507871962 @default.
- W2593353214 cites W3023475953 @default.
- W2593353214 cites W4238163958 @default.
- W2593353214 cites W45534775 @default.
- W2593353214 cites W95923283 @default.
- W2593353214 doi "https://doi.org/10.1038/srep43697" @default.
- W2593353214 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5333102" @default.
- W2593353214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28252048" @default.
- W2593353214 hasPublicationYear "2017" @default.
- W2593353214 type Work @default.
- W2593353214 sameAs 2593353214 @default.
- W2593353214 citedByCount "34" @default.
- W2593353214 countsByYear W25933532142017 @default.
- W2593353214 countsByYear W25933532142018 @default.
- W2593353214 countsByYear W25933532142019 @default.