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- W2593398334 abstract "Part of the innate immune response, inflammasomes are multiprotein intracellular complexes that detect pathogens and activate the proinflammatory cytokines IL-1β and IL-18, via caspase-1, and induce pyroptosis. The effector pathways of the inflammasome can act at different levels to prevent or resolve infection, or eliminate the infectious agent itself. In this Review, the authors discuss the role of inflammasomes in the pathogenesis of UTI and consider how better understanding of their mechanisms might lead to new diagnostic and therapeutic approaches for UTI. Urinary tract infections (UTIs) cause a huge burden of morbidity worldwide with recurrent UTIs becoming increasingly frequent owing to the emergence of antibiotic-resistant bacterial strains. Interactions between the innate and adaptive immune responses to pathogens colonizing the urinary tract have been the focus of much research. Inflammasomes are part of the innate immune defence and can respond rapidly to infectious insult. Assembly of the multiprotein inflammasome complex activates caspase-1, processes proinflammatory cytokines IL-1β and IL-18, and induces pyroptosis. These effector pathways, in turn, act at different levels to either prevent or resolve infection, or eliminate the infectious agent itself. In certain instances, inflammasome activation promotes tissue pathology; however, the precise functions of inflammasomes in UTIs remain unexplored. An improved understanding of inflammasomes could provide novel approaches for the design of diagnostics and therapeutics for complicated UTIs, enabling us to overcome the challenge of drug resistance." @default.
- W2593398334 created "2017-03-16" @default.
- W2593398334 creator A5015841302 @default.
- W2593398334 creator A5028788909 @default.
- W2593398334 creator A5033171385 @default.
- W2593398334 creator A5046443494 @default.
- W2593398334 date "2017-03-07" @default.
- W2593398334 modified "2023-10-18" @default.
- W2593398334 title "Immunity to uropathogens: the emerging roles of inflammasomes" @default.
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