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- W2593442246 abstract "Objective: To clarify the potential benefit of treating patients with stroke related to large vessel obstruction using intra-arterial treatment.Background: The study of arterial lumen clearing technologies for the treatment of acute ischemic stroke has yielded mixed results.Methods: A meta-analysis of randomized controlled trials published that compared standard therapy with intravenous tissue plasminogen activator (IVtPA) for thrombolysis to intra-arterial therapies in patients with acute stroke was performed. All studies reported were analyzed as one group and studies documenting patients with large vessel obstruction were analyzed as a second group. The standardized mean difference (SMD) and the odds ratio (OR) of the dichotomized outcomes of Modified Rankin Scale (mRS) of these trials was calculated.Results: Nine trials were identified with 2,711 patients treated. Meta-analysis of all studies, with and without large vessel obstruction documented, showed a significant benefit with intra-arterial therapy (SMD: 0.22 + 0.041; P=0.003). The dichotomized outcomes of mRS of these trials showed significant improvement (OR: 1.66 -2.43 in four of the five treatment arm groups examined). Meta-analysis of all publications with large vessel obstruction documented as an entry criteria showed a greater significant benefit with intra-arterial therapy (SMD: 0.35 + 0.05; P<0.001). The dichotomized outcomes of mRS of these trials showed significant improvement (OR: 1.36 -2.38 in all five treatment arm groups examined).Conclusion: This meta-analysis confirms that treatment of intra-arterial thrombus in patients with acute stroke is associated with improved outcomes as measured by mRS. Patient selection, standard treatment, and study treatment factors contributed to the statistical evaluation of inter study heterogeneity and may have contributed to different study outcomes. Disclosure: Dr. Lakhan has nothing to disclose. Dr. McClellan has nothing to disclose. Dr. Nguyen has nothing to disclose." @default.
- W2593442246 created "2017-03-16" @default.
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- W2593442246 date "2016-04-05" @default.
- W2593442246 modified "2023-09-26" @default.
- W2593442246 title "Intra-Arterial Treatment for Acute Ischemic Stroke: A Meta-Analysis (P2.286)" @default.
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