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• W2593444865 startingPage "90" @default.
• W2593444865 abstract "The gastrointestinal tract is a well-characterized target of thyroid hormones and thyroid hormone nuclear receptors TRs, as extensively described in the literature. The paradigm is its important remodelling in amphibians during thyroid hormone-dependent metamorphosis. Interestingly, several studies have described the conservation of this hormonal signal during intestinal development in mammals. Additional data suggested that it may also play a role in intestinal homeostasis, stem cell physiology and progenitor commitment as well as in tumour development. It is worth underlining that in the mammalian intestine the functionality of the TRα1 receptor is coordinated and integrated with other signalling pathways, such as Wnt and Notch, specifically at the level of stem/progenitor cell populations. Here, we summarize these data and concepts and discuss this new role for thyroid hormones and the TRα1 receptor in the biology of intestinal epithelial precursor cells." @default.
• W2593444865 created "2017-03-16" @default.
• W2593444865 creator A5038888136 @default.
• W2593444865 creator A5043695535 @default.
• W2593444865 creator A5072143635 @default.
• W2593444865 date "2017-12-01" @default.
• W2593444865 modified "2023-10-14" @default.
• W2593444865 title "Thyroid hormone regulation of intestinal epithelial stem cell biology" @default.
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