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• W2593447007 startingPage "e1600487" @default.
• W2593447007 abstract "Potentilla parvifolia Fisch. (Rosaceae) is a traditional medicinal plant in P. R. China. In this study, seven flavonoids, ayanin (1), tricin (2), quercetin (3), tiliroside (4), miquelianin (5), isoquercitrin (6), and astragalin (7), were separated and purified from ethyl acetate extractive fractions from ethanol extracts of P. parvifolia using a combination of sevaral chromatographic methods. The human neuroblastoma SH-SY5Y cells were differentiated with all trans-retinoic acid and treated with okadaic acid to induce tau protein phosphorylation and synaptic atrophy, which could establish an Alzheimer's disease cell model. The neuroprotective effects of these flavonoids in cellular were evaluated in vitro by this cell model. Results from the Western blot and morphology analysis suggested that compounds 3 and 4 had the better neuroprotective effects." @default.
• W2593447007 created "2017-03-16" @default.
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• W2593447007 date "2017-04-25" @default.
• W2593447007 modified "2023-10-06" @default.
• W2593447007 title "Flavonoids from <i>Potentilla parvifolia </i> <scp>Fisch</scp> . and Their Neuroprotective Effects in Human Neuroblastoma SH-SY5Y Cells <i>in vitro</i>" @default.
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• W2593447007 doi "https://doi.org/10.1002/cbdv.201600487" @default.
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• W2593447007 hasPublicationYear "2017" @default.
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