FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2593448618> ?p ?o ?g. }

• W2593448618 endingPage "901" @default.
• W2593448618 startingPage "894" @default.
• W2593448618 abstract "Hepatocellular carcinoma(HCC) is one of the most common malignancies worldwide, however, drug resistance is still a tough problem of it. As in many other cancers, p53 mutations are commonly observed in HCCs (Hussain et al., 2007; Levine et al., 1994) [1], [2]. Tumor tissues with mutant p53 seems to be more aggressive and resist to chemotherapy than that harboring wide-type p53 (Harris and Hollstein, 1994; Parrales and Iwakuma, 2015) [3], [4]. (−)-Curine, a novel bisbenzylisoquinoline alkaloid, is one of the main components isolated from the roots of Cyclea wattii. Here, it was found to exert cytotoxity on hepatocellular carcinoma (HCC) cells regardless of p53 status. We found that (−)-curine induced G1 arrest and cell death in HepG2 cells with wild-type p53 as well as Huh-7 cells with mutant p53. In HepG2 cells, knocking down of p53 did not change its cellular responses to (−)-curine, and same degree of G1 arrest and cell death were occurred after p53 knockdown. Taken together, our data demonstrate that (−)-curine can inhibit viability of hepatocellular carcinoma cells in regardless of p53 status. It shed light on new therapy methods for HCC." @default.
• W2593448618 created "2017-03-16" @default.
• W2593448618 creator A5044210009 @default.
• W2593448618 creator A5055908165 @default.
• W2593448618 creator A5076092727 @default.
• W2593448618 creator A5085728589 @default.
• W2593448618 date "2017-05-01" @default.
• W2593448618 modified "2023-10-16" @default.
• W2593448618 title "(−)-Curine induces cell cycle arrest and cell death in hepatocellular carcinoma cells in a p53-independent way" @default.
• W2593448618 cites W1530007295 @default.
• W2593448618 cites W1650797637 @default.
• W2593448618 cites W1920572469 @default.
• W2593448618 cites W1979319210 @default.
• W2593448618 cites W1983109993 @default.
• W2593448618 cites W2001953597 @default.
• W2593448618 cites W2005889402 @default.
• W2593448618 cites W2010698881 @default.
• W2593448618 cites W2025108978 @default.
• W2593448618 cites W2026541510 @default.
• W2593448618 cites W2027846061 @default.
• W2593448618 cites W2042753075 @default.
• W2593448618 cites W2050582172 @default.
• W2593448618 cites W2054027376 @default.
• W2593448618 cites W2075707444 @default.
• W2593448618 cites W2081641598 @default.
• W2593448618 cites W2102951681 @default.
• W2593448618 cites W2108939879 @default.
• W2593448618 cites W2110836068 @default.
• W2593448618 cites W2111689885 @default.
• W2593448618 cites W2144597430 @default.
• W2593448618 cites W2322457163 @default.
• W2593448618 cites W2322840303 @default.
• W2593448618 cites W2411308901 @default.
• W2593448618 doi "https://doi.org/10.1016/j.biopha.2017.01.148" @default.
• W2593448618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28292017" @default.
• W2593448618 hasPublicationYear "2017" @default.
• W2593448618 type Work @default.
• W2593448618 sameAs 2593448618 @default.
• W2593448618 citedByCount "9" @default.
• W2593448618 countsByYear W25934486182018 @default.
• W2593448618 countsByYear W25934486182019 @default.
• W2593448618 countsByYear W25934486182020 @default.
• W2593448618 countsByYear W25934486182022 @default.
• W2593448618 countsByYear W25934486182023 @default.
• W2593448618 crossrefType "journal-article" @default.
• W2593448618 hasAuthorship W2593448618A5044210009 @default.
• W2593448618 hasAuthorship W2593448618A5055908165 @default.
• W2593448618 hasAuthorship W2593448618A5076092727 @default.
• W2593448618 hasAuthorship W2593448618A5085728589 @default.
• W2593448618 hasConcept C104317684 @default.
• W2593448618 hasConcept C105696609 @default.
• W2593448618 hasConcept C143065580 @default.
• W2593448618 hasConcept C1491633281 @default.
• W2593448618 hasConcept C173396325 @default.
• W2593448618 hasConcept C190283241 @default.
• W2593448618 hasConcept C2778019345 @default.
• W2593448618 hasConcept C2779314089 @default.
• W2593448618 hasConcept C29537977 @default.
• W2593448618 hasConcept C31573885 @default.
• W2593448618 hasConcept C502942594 @default.
• W2593448618 hasConcept C53227056 @default.
• W2593448618 hasConcept C54355233 @default.
• W2593448618 hasConcept C71924100 @default.
• W2593448618 hasConcept C81885089 @default.
• W2593448618 hasConcept C86803240 @default.
• W2593448618 hasConceptScore W2593448618C104317684 @default.
• W2593448618 hasConceptScore W2593448618C105696609 @default.
• W2593448618 hasConceptScore W2593448618C143065580 @default.
• W2593448618 hasConceptScore W2593448618C1491633281 @default.
• W2593448618 hasConceptScore W2593448618C173396325 @default.
• W2593448618 hasConceptScore W2593448618C190283241 @default.
• W2593448618 hasConceptScore W2593448618C2778019345 @default.
• W2593448618 hasConceptScore W2593448618C2779314089 @default.
• W2593448618 hasConceptScore W2593448618C29537977 @default.
• W2593448618 hasConceptScore W2593448618C31573885 @default.
• W2593448618 hasConceptScore W2593448618C502942594 @default.
• W2593448618 hasConceptScore W2593448618C53227056 @default.
• W2593448618 hasConceptScore W2593448618C54355233 @default.
• W2593448618 hasConceptScore W2593448618C71924100 @default.
• W2593448618 hasConceptScore W2593448618C81885089 @default.
• W2593448618 hasConceptScore W2593448618C86803240 @default.
• W2593448618 hasFunder F4320321001 @default.
• W2593448618 hasLocation W25934486181 @default.
• W2593448618 hasLocation W25934486182 @default.
• W2593448618 hasOpenAccess W2593448618 @default.
• W2593448618 hasPrimaryLocation W25934486181 @default.
• W2593448618 hasRelatedWork W1911027473 @default.
• W2593448618 hasRelatedWork W1992314595 @default.
• W2593448618 hasRelatedWork W1999157020 @default.
• W2593448618 hasRelatedWork W2035703032 @default.
• W2593448618 hasRelatedWork W2065618301 @default.
• W2593448618 hasRelatedWork W2117410915 @default.
• W2593448618 hasRelatedWork W2375390396 @default.
• W2593448618 hasRelatedWork W3161864617 @default.
• W2593448618 hasRelatedWork W4362559856 @default.
• W2593448618 hasRelatedWork W2188205072 @default.
• W2593448618 hasVolume "89" @default.
• W2593448618 isParatext "false" @default.

• next