FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2593468578> ?p ?o ?g. }

• W2593468578 endingPage "954" @default.
• W2593468578 startingPage "943" @default.
• W2593468578 abstract "Characterizing nicotine pharmacokinetics is challenging in the presence of background exposure. We performed a combined retrospective population pharmacokinetic analysis of 8 trials, including exposure to Tobacco Heating System and cigarettes (both inhaled), nicotine nasal spray and oral nicotine gum.Data from 4 single product use trials were used to develop a population pharmacokinetic model with Phoenix® NLME™ and to derive exposure parameters. Data from 4 separate ad libitum use studies were used for external validation. A total of 702 healthy adult smokers (54% males; 21-66 years of age; smoking ≥10 cigarettes/day; from US, Europe and Japan) were eligible for participation.Two-compartment linear disposition combined with zero-order absorption model was adequate to describe nicotine pharmacokinetics, and a mono-exponentially decreasing background component was utilized to account for nicotine carry-over effects. Apparent nicotine clearance was typically 0.407 L/min in males and 26% higher in females (68% inter-individual variability). Bioavailability was product-specific, decreased with increasing nicotine ISO yield, and increased with increasing body weight. Absorption duration was apparently prolonged with nicotine gum. The typical initial and terminal half-lives were 1.35 and 17 h, respectively. The presence of menthol did not impact the determinants of the area under the curve. The model adequately described the external validation data.The population model was able to describe in different populations the nicotine pharmacokinetics after single product use and after 4 days of ad libitum use of Tobacco Heating System, cigarettes, and of different nicotine replacement therapies with various routes of administration." @default.
• W2593468578 created "2017-03-16" @default.
• W2593468578 creator A5006825870 @default.
• W2593468578 creator A5007522604 @default.
• W2593468578 creator A5011179271 @default.
• W2593468578 creator A5018798462 @default.
• W2593468578 creator A5037093409 @default.
• W2593468578 creator A5087638288 @default.
• W2593468578 date "2017-03-10" @default.
• W2593468578 modified "2023-10-13" @default.
• W2593468578 title "Nicotine Population Pharmacokinetics in Healthy Adult Smokers: A Retrospective Analysis" @default.
• W2593468578 cites W1509693321 @default.
• W2593468578 cites W1966015088 @default.
• W2593468578 cites W1972456437 @default.
• W2593468578 cites W2003257082 @default.
• W2593468578 cites W2005069607 @default.
• W2593468578 cites W2023749251 @default.
• W2593468578 cites W2036665059 @default.
• W2593468578 cites W2040845177 @default.
• W2593468578 cites W2041992280 @default.
• W2593468578 cites W2048099302 @default.
• W2593468578 cites W2052727647 @default.
• W2593468578 cites W2061790725 @default.
• W2593468578 cites W2083668821 @default.
• W2593468578 cites W2095842076 @default.
• W2593468578 cites W2113515521 @default.
• W2593468578 cites W2116438644 @default.
• W2593468578 cites W2116515517 @default.
• W2593468578 cites W2134552151 @default.
• W2593468578 cites W2140838870 @default.
• W2593468578 cites W2161711938 @default.
• W2593468578 cites W2169463741 @default.
• W2593468578 cites W2267264234 @default.
• W2593468578 cites W2474819169 @default.
• W2593468578 doi "https://doi.org/10.1007/s13318-017-0405-2" @default.
• W2593468578 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5681983" @default.
• W2593468578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28283988" @default.
• W2593468578 hasPublicationYear "2017" @default.
• W2593468578 type Work @default.
• W2593468578 sameAs 2593468578 @default.
• W2593468578 citedByCount "15" @default.
• W2593468578 countsByYear W25934685782017 @default.
• W2593468578 countsByYear W25934685782018 @default.
• W2593468578 countsByYear W25934685782019 @default.
• W2593468578 countsByYear W25934685782020 @default.
• W2593468578 countsByYear W25934685782021 @default.
• W2593468578 countsByYear W25934685782022 @default.
• W2593468578 countsByYear W25934685782023 @default.
• W2593468578 crossrefType "journal-article" @default.
• W2593468578 hasAuthorship W2593468578A5006825870 @default.
• W2593468578 hasAuthorship W2593468578A5007522604 @default.
• W2593468578 hasAuthorship W2593468578A5011179271 @default.
• W2593468578 hasAuthorship W2593468578A5018798462 @default.
• W2593468578 hasAuthorship W2593468578A5037093409 @default.
• W2593468578 hasAuthorship W2593468578A5087638288 @default.
• W2593468578 hasBestOaLocation W25934685781 @default.
• W2593468578 hasConcept C112705442 @default.
• W2593468578 hasConcept C126322002 @default.
• W2593468578 hasConcept C142724271 @default.
• W2593468578 hasConcept C178790620 @default.
• W2593468578 hasConcept C181389837 @default.
• W2593468578 hasConcept C185592680 @default.
• W2593468578 hasConcept C204787440 @default.
• W2593468578 hasConcept C27081682 @default.
• W2593468578 hasConcept C2777843972 @default.
• W2593468578 hasConcept C2778887763 @default.
• W2593468578 hasConcept C2779547902 @default.
• W2593468578 hasConcept C2780194911 @default.
• W2593468578 hasConcept C2780973058 @default.
• W2593468578 hasConcept C2908647359 @default.
• W2593468578 hasConcept C71924100 @default.
• W2593468578 hasConcept C85663871 @default.
• W2593468578 hasConcept C98274493 @default.
• W2593468578 hasConcept C99454951 @default.
• W2593468578 hasConceptScore W2593468578C112705442 @default.
• W2593468578 hasConceptScore W2593468578C126322002 @default.
• W2593468578 hasConceptScore W2593468578C142724271 @default.
• W2593468578 hasConceptScore W2593468578C178790620 @default.
• W2593468578 hasConceptScore W2593468578C181389837 @default.
• W2593468578 hasConceptScore W2593468578C185592680 @default.
• W2593468578 hasConceptScore W2593468578C204787440 @default.
• W2593468578 hasConceptScore W2593468578C27081682 @default.
• W2593468578 hasConceptScore W2593468578C2777843972 @default.
• W2593468578 hasConceptScore W2593468578C2778887763 @default.
• W2593468578 hasConceptScore W2593468578C2779547902 @default.
• W2593468578 hasConceptScore W2593468578C2780194911 @default.
• W2593468578 hasConceptScore W2593468578C2780973058 @default.
• W2593468578 hasConceptScore W2593468578C2908647359 @default.
• W2593468578 hasConceptScore W2593468578C71924100 @default.
• W2593468578 hasConceptScore W2593468578C85663871 @default.
• W2593468578 hasConceptScore W2593468578C98274493 @default.
• W2593468578 hasConceptScore W2593468578C99454951 @default.
• W2593468578 hasIssue "6" @default.
• W2593468578 hasLocation W25934685781 @default.
• W2593468578 hasLocation W25934685782 @default.
• W2593468578 hasLocation W25934685783 @default.
• W2593468578 hasLocation W25934685784 @default.
• W2593468578 hasOpenAccess W2593468578 @default.

• next