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- W2593485651 endingPage "180" @default.
- W2593485651 startingPage "162" @default.
- W2593485651 abstract "Satellite cells, also known as muscle stem cells, are responsible for skeletal muscle growth and repair in mammals. Pax7 and Pax3 transcription factors are established satellite cell markers required for muscle development and regeneration, and there is great interest in identifying additional factors that regulate satellite cell proliferation, differentiation, and/or skeletal muscle regeneration. Due to the powerful regenerative capacity of many zebrafish tissues, even in adults, we are exploring the regenerative potential of adult zebrafish skeletal muscle. Here, we show that adult zebrafish skeletal muscle contains cells similar to mammalian satellite cells. Adult zebrafish satellite-like cells have dense heterochromatin, express Pax7 and Pax3, proliferate in response to injury, and show peak myogenic responses 4–5 days post-injury (dpi). Furthermore, using a pax7a-driven GFP reporter, we present evidence implicating satellite-like cells as a possible source of new muscle. In lieu of central nucleation, which distinguishes regenerating myofibers in mammals, we describe several characteristics that robustly identify newly-forming myofibers from surrounding fibers in injured adult zebrafish muscle. These characteristics include partially overlapping expression in satellite-like cells and regenerating myofibers of two RNA-binding proteins Rbfox2 and Rbfoxl1, known to regulate embryonic muscle development and function. Finally, by analyzing pax7a; pax7b double mutant zebrafish, we show that Pax7 is required for adult skeletal muscle repair, as it is in the mouse." @default.
- W2593485651 created "2017-03-16" @default.
- W2593485651 creator A5001440469 @default.
- W2593485651 creator A5023472472 @default.
- W2593485651 creator A5029850300 @default.
- W2593485651 creator A5030666607 @default.
- W2593485651 creator A5044513246 @default.
- W2593485651 creator A5059046090 @default.
- W2593485651 creator A5082136653 @default.
- W2593485651 creator A5085908673 @default.
- W2593485651 date "2017-04-01" @default.
- W2593485651 modified "2023-10-17" @default.
- W2593485651 title "Satellite-like cells contribute to pax7-dependent skeletal muscle repair in adult zebrafish" @default.
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