Matches in SemOpenAlex for { <https://semopenalex.org/work/W2593534148> ?p ?o ?g. }
- W2593534148 endingPage "1504" @default.
- W2593534148 startingPage "1491" @default.
- W2593534148 abstract "Vaccines targeting glycan structures at the surface of pathogenic microbes must overcome the inherent T cell–independent nature of immune responses against glycans. Carbohydrate conjugate vaccines achieve this by coupling bacterial polysaccharides to a carrier protein that recruits heterologous CD4 T cells to help B cell maturation. Yet they most often produce low- to medium-affinity immune responses of limited duration in immunologically fit individuals and disappointing results in the elderly and immunocompromised patients. Here, we hypothesized that these limitations result from suboptimal T cell help. To produce the next generation of more efficacious conjugate vaccines, we have explored a synthetic design aimed at focusing both B cell and T cell recognition to a single short glycan displayed at the surface of a virus-like particle. We tested and established the proof of concept of this approach for 2 serotypes of Streptococcus pneumoniae. In both cases, these vaccines elicited serotype-specific, protective, and long-lasting IgG antibodies of nanomolar affinity against the target glycans in mice. We further identified a requirement for CD4 T cells in the anti-glycan antibody response. Our findings establish the design principles for improved glycan conjugate vaccines. We surmise that the same approach can be used for any microbial glycan of interest." @default.
- W2593534148 created "2017-03-16" @default.
- W2593534148 creator A5007598672 @default.
- W2593534148 creator A5010315360 @default.
- W2593534148 creator A5012554076 @default.
- W2593534148 creator A5014729402 @default.
- W2593534148 creator A5016066687 @default.
- W2593534148 creator A5016067033 @default.
- W2593534148 creator A5021512226 @default.
- W2593534148 creator A5023146929 @default.
- W2593534148 creator A5023593956 @default.
- W2593534148 creator A5030160770 @default.
- W2593534148 creator A5031452464 @default.
- W2593534148 creator A5032114980 @default.
- W2593534148 creator A5036614156 @default.
- W2593534148 creator A5038894124 @default.
- W2593534148 creator A5039824850 @default.
- W2593534148 creator A5040986807 @default.
- W2593534148 creator A5044305711 @default.
- W2593534148 creator A5046086498 @default.
- W2593534148 creator A5056409921 @default.
- W2593534148 creator A5059205572 @default.
- W2593534148 creator A5061712789 @default.
- W2593534148 creator A5062245393 @default.
- W2593534148 creator A5086992958 @default.
- W2593534148 date "2017-03-13" @default.
- W2593534148 modified "2023-10-18" @default.
- W2593534148 title "T cells control the generation of nanomolar-affinity anti-glycan antibodies" @default.
- W2593534148 cites W1484580130 @default.
- W2593534148 cites W1515043996 @default.
- W2593534148 cites W1519712688 @default.
- W2593534148 cites W1523937528 @default.
- W2593534148 cites W1576435529 @default.
- W2593534148 cites W1748261727 @default.
- W2593534148 cites W1845427115 @default.
- W2593534148 cites W1884435079 @default.
- W2593534148 cites W1902656581 @default.
- W2593534148 cites W1903636206 @default.
- W2593534148 cites W1906135384 @default.
- W2593534148 cites W1928693942 @default.
- W2593534148 cites W1968894936 @default.
- W2593534148 cites W1971045102 @default.
- W2593534148 cites W1983317208 @default.
- W2593534148 cites W1987519563 @default.
- W2593534148 cites W1988422289 @default.
- W2593534148 cites W1989321959 @default.
- W2593534148 cites W1991780615 @default.
- W2593534148 cites W1992743196 @default.
- W2593534148 cites W2001775594 @default.
- W2593534148 cites W2005242840 @default.
- W2593534148 cites W2007027030 @default.
- W2593534148 cites W2012619409 @default.
- W2593534148 cites W2017312699 @default.
- W2593534148 cites W2017992888 @default.
- W2593534148 cites W2018238850 @default.
- W2593534148 cites W2021878803 @default.
- W2593534148 cites W2023964275 @default.
- W2593534148 cites W2024798162 @default.
- W2593534148 cites W2027947833 @default.
- W2593534148 cites W2031394441 @default.
- W2593534148 cites W2034346419 @default.
- W2593534148 cites W2042715922 @default.
- W2593534148 cites W2045465609 @default.
- W2593534148 cites W2046358537 @default.
- W2593534148 cites W2046427690 @default.
- W2593534148 cites W2058963377 @default.
- W2593534148 cites W2060640530 @default.
- W2593534148 cites W2070132182 @default.
- W2593534148 cites W2070597700 @default.
- W2593534148 cites W2078913377 @default.
- W2593534148 cites W2082871926 @default.
- W2593534148 cites W2082947088 @default.
- W2593534148 cites W2086333958 @default.
- W2593534148 cites W2087585684 @default.
- W2593534148 cites W2090916507 @default.
- W2593534148 cites W2092545077 @default.
- W2593534148 cites W2092600829 @default.
- W2593534148 cites W2096704107 @default.
- W2593534148 cites W2100761378 @default.
- W2593534148 cites W2102686641 @default.
- W2593534148 cites W2103794578 @default.
- W2593534148 cites W2108508060 @default.
- W2593534148 cites W2111354542 @default.
- W2593534148 cites W2111560491 @default.
- W2593534148 cites W2112765785 @default.
- W2593534148 cites W2113575403 @default.
- W2593534148 cites W2121228279 @default.
- W2593534148 cites W2121477549 @default.
- W2593534148 cites W2124252269 @default.
- W2593534148 cites W2125748493 @default.
- W2593534148 cites W2128013943 @default.
- W2593534148 cites W2128666074 @default.
- W2593534148 cites W2129091558 @default.
- W2593534148 cites W2129861049 @default.
- W2593534148 cites W2130421043 @default.
- W2593534148 cites W2131971532 @default.
- W2593534148 cites W2135019751 @default.
- W2593534148 cites W2138598318 @default.