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- W2593542847 abstract "Lysosomal storage diseases (LSDs) are inherited metabolic disorders characterized by the accumulation of different types of substrates in the lysosome. With a multisystemic involvement, LSDs often present a very broad clinical spectrum. In many LSDs, alterations of the immune system were described. Special emphasis was given to Natural Killer T (NKT) cells, a population of lipid-specific T cells that is activated by lipid antigens bound to CD1d (cluster of differentiation 1 d) molecules at the surface of antigen-presenting cells. These cells have important functions in cancer, infection, and autoimmunity and were altered in a variety of LSDs’ mouse models. In some cases, the observed decrease was attributed to defects in either lipid antigen availability, trafficking, processing, or loading in CD1d. Here, we review the current knowledge about NKT cells in the context of LSDs, including the alterations detected, the proposed mechanisms to explain these defects, and the relevance of these findings for disease pathology. Furthermore, the effect of enzyme replacement therapy on NKT cells is also discussed." @default.
- W2593542847 created "2017-03-16" @default.
- W2593542847 creator A5008205313 @default.
- W2593542847 creator A5021782091 @default.
- W2593542847 creator A5085035957 @default.
- W2593542847 date "2017-02-25" @default.
- W2593542847 modified "2023-09-29" @default.
- W2593542847 title "From Lysosomal Storage Diseases to NKT Cell Activation and Back" @default.
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- W2593542847 doi "https://doi.org/10.3390/ijms18030502" @default.
- W2593542847 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5372518" @default.
- W2593542847 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28245613" @default.
- W2593542847 hasPublicationYear "2017" @default.
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