FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2593588069> ?p ?o ?g. }

• W2593588069 endingPage "1081" @default.
• W2593588069 startingPage "1072" @default.
• W2593588069 abstract "Background/purpose The objective of this study was to explore the impact of systemic lupus erythematosus and belimumab given in addition to standard of care therapy on 13-valent conjugated pneumococcal vaccine (PCV13) response. Methods Forty-seven systemic lupus erythematosus patients and 21 healthy controls were immunized with a single dose of 13-valent conjugated pneumococcal vaccine. Forty systemic lupus erythematosus patients were treated with traditional disease-modifying anti rheumatic drugs, 11 of those received belimumab in addition, and 32 patients were treated with concomitant prednisolone. Quantification of serotype specific IgG levels to 12 pneumococcal capsular polysaccharides was performed in serum taken before and four to six weeks after vaccination using multiplex fluorescent microsphere immunoassay. IgG levels against serotypes 23F and 6B were also analyzed using standard enzyme-linked immunosorbent assays. Opsonophagocytic assay was performed on serotype 23F to evaluate the functionality of the antibodies. Pre- and post-vaccination log transformed antibody levels were compared to determine the impact of systemic lupus erythematosus diagnosis and different treatments on antibody response. Results Systemic lupus erythematosus patients as a group showed lower post-vaccination antibody levels and lower fold increase of antibody levels after vaccination compared to controls ( p = 0.02 and p = 0.009, respectively). Systemic lupus erythematosus patients treated with belimumab in addition to standard of care therapy or with only hydroxychloroquine did not differ compared to controls, whereas the other treatment groups had significantly lower fold increase of post-vaccination antibody levels. Higher age was associated with lower post-vaccination antibody levels among systemic lupus erythematosus patients. Conclusion Belimumab given in addition to traditional disease-modifying anti rheumatic drugs or prednisolone did not further impair antibody response to 13-valent conjugated pneumococcal vaccine." @default.
• W2593588069 created "2017-03-16" @default.
• W2593588069 creator A5002914719 @default.
• W2593588069 creator A5015705695 @default.
• W2593588069 creator A5015932797 @default.
• W2593588069 creator A5028042265 @default.
• W2593588069 creator A5038826018 @default.
• W2593588069 creator A5051723917 @default.
• W2593588069 creator A5064079395 @default.
• W2593588069 creator A5064707092 @default.
• W2593588069 creator A5080827884 @default.
• W2593588069 creator A5086180632 @default.
• W2593588069 date "2017-02-26" @default.
• W2593588069 modified "2023-10-18" @default.
• W2593588069 title "Treatment with belimumab in systemic lupus erythematosus does not impair antibody response to 13-valent pneumococcal conjugate vaccine" @default.
• W2593588069 cites W1959216194 @default.
• W2593588069 cites W1975085076 @default.
• W2593588069 cites W1977402193 @default.
• W2593588069 cites W1991601117 @default.
• W2593588069 cites W1998636293 @default.
• W2593588069 cites W2018707227 @default.
• W2593588069 cites W2019830518 @default.
• W2593588069 cites W2021201394 @default.
• W2593588069 cites W2022147863 @default.
• W2593588069 cites W2023116174 @default.
• W2593588069 cites W2023284037 @default.
• W2593588069 cites W2042059215 @default.
• W2593588069 cites W2072498492 @default.
• W2593588069 cites W2083912181 @default.
• W2593588069 cites W2091675224 @default.
• W2593588069 cites W2095955512 @default.
• W2593588069 cites W2098629752 @default.
• W2593588069 cites W2104863857 @default.
• W2593588069 cites W2113985836 @default.
• W2593588069 cites W2114386527 @default.
• W2593588069 cites W2121745520 @default.
• W2593588069 cites W2131457901 @default.
• W2593588069 cites W2136149088 @default.
• W2593588069 cites W2146203649 @default.
• W2593588069 cites W2148069290 @default.
• W2593588069 cites W2155454938 @default.
• W2593588069 cites W2166448515 @default.
• W2593588069 cites W2183052484 @default.
• W2593588069 cites W2199895174 @default.
• W2593588069 cites W2232105734 @default.
• W2593588069 cites W2296460211 @default.
• W2593588069 cites W4247094029 @default.
• W2593588069 doi "https://doi.org/10.1177/0961203317695465" @default.
• W2593588069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28420056" @default.
• W2593588069 hasPublicationYear "2017" @default.
• W2593588069 type Work @default.
• W2593588069 sameAs 2593588069 @default.
• W2593588069 citedByCount "32" @default.
• W2593588069 countsByYear W25935880692017 @default.
• W2593588069 countsByYear W25935880692018 @default.
• W2593588069 countsByYear W25935880692019 @default.
• W2593588069 countsByYear W25935880692020 @default.
• W2593588069 countsByYear W25935880692021 @default.
• W2593588069 countsByYear W25935880692022 @default.
• W2593588069 countsByYear W25935880692023 @default.
• W2593588069 crossrefType "journal-article" @default.
• W2593588069 hasAuthorship W2593588069A5002914719 @default.
• W2593588069 hasAuthorship W2593588069A5015705695 @default.
• W2593588069 hasAuthorship W2593588069A5015932797 @default.
• W2593588069 hasAuthorship W2593588069A5028042265 @default.
• W2593588069 hasAuthorship W2593588069A5038826018 @default.
• W2593588069 hasAuthorship W2593588069A5051723917 @default.
• W2593588069 hasAuthorship W2593588069A5064079395 @default.
• W2593588069 hasAuthorship W2593588069A5064707092 @default.
• W2593588069 hasAuthorship W2593588069A5080827884 @default.
• W2593588069 hasAuthorship W2593588069A5086180632 @default.
• W2593588069 hasConcept C126322002 @default.
• W2593588069 hasConcept C159654299 @default.
• W2593588069 hasConcept C170286685 @default.
• W2593588069 hasConcept C203014093 @default.
• W2593588069 hasConcept C22070199 @default.
• W2593588069 hasConcept C2775915377 @default.
• W2593588069 hasConcept C2776912625 @default.
• W2593588069 hasConcept C2778453870 @default.
• W2593588069 hasConcept C2779134260 @default.
• W2593588069 hasConcept C2779664119 @default.
• W2593588069 hasConcept C2780420688 @default.
• W2593588069 hasConcept C2781205201 @default.
• W2593588069 hasConcept C2781253189 @default.
• W2593588069 hasConcept C3020803494 @default.
• W2593588069 hasConcept C501593827 @default.
• W2593588069 hasConcept C71924100 @default.
• W2593588069 hasConcept C86803240 @default.
• W2593588069 hasConcept C89423630 @default.
• W2593588069 hasConceptScore W2593588069C126322002 @default.
• W2593588069 hasConceptScore W2593588069C159654299 @default.
• W2593588069 hasConceptScore W2593588069C170286685 @default.
• W2593588069 hasConceptScore W2593588069C203014093 @default.
• W2593588069 hasConceptScore W2593588069C22070199 @default.
• W2593588069 hasConceptScore W2593588069C2775915377 @default.
• W2593588069 hasConceptScore W2593588069C2776912625 @default.
• W2593588069 hasConceptScore W2593588069C2778453870 @default.
• W2593588069 hasConceptScore W2593588069C2779134260 @default.

• next