FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2593607777> ?p ?o ?g. }

• W2593607777 endingPage "3332" @default.
• W2593607777 startingPage "3324" @default.
• W2593607777 abstract "Effects of adding 1 mol % of gramicidin-A on the biochemical properties of coexisting liquid-ordered and liquid-disordered (Lo + Ld) membrane domains were investigated. Quaternary giant unilamellar vesicles (GUV) of di18:1PC(DOPC)/di18:0PC(DSPC)/cholesterol/gramicidin-A were prepared using our recently developed damp-film method. The phase boundary of Lo + Ld coexisting region was determined using video fluorescence microscopy. Through fitting Nile Red fluorescence emission spectra, the thermodynamic tie-lines in the Lo + Ld two-phase region were determined. We found that at 1 mol % (i.e., ∼7% of membrane area), gramicidin peptides alter the phase boundary and thermodynamic tie-lines. Gramicidin abolishes the coexisting phases at some lipid compositions but induces phase separation at others. Previous studies of gramicidin emphasize the local perturbation of bilayer thickness adjacent to the protein through the interaction of “hydrophobic mismatch”. For the first time, it becomes clear that adding gramicidin produces significant long-range and global effects on the structure of membrane domains: it alters the overall lipid compositions and bilayer thicknesses of coexisting Lo and Ld domains. We also found that gramicidin partitions favorably into the Ld phase. Adding gramicidin decreases cholesterol in the Ld phase and increases cholesterol in the Lo phase. Those compositional changes broaden the bilayer thickness difference between Lo and Ld domains and facilitate preferential partition of gramicidin into thinner Ld domains. Our results demonstrate that membrane proteins play significant roles in determining lipid compositions and bilayer thicknesses of biomembrane domains." @default.
• W2593607777 created "2017-03-16" @default.
• W2593607777 creator A5031163364 @default.
• W2593607777 creator A5040700979 @default.
• W2593607777 creator A5046541656 @default.
• W2593607777 date "2017-03-20" @default.
• W2593607777 modified "2023-09-28" @default.
• W2593607777 title "Gramicidin Peptides Alter Global Lipid Compositions and Bilayer Thicknesses of Coexisting Liquid-Ordered and Liquid-Disordered Membrane Domains" @default.
• W2593607777 cites W1964477055 @default.
• W2593607777 cites W1964728048 @default.
• W2593607777 cites W1967986789 @default.
• W2593607777 cites W1969461041 @default.
• W2593607777 cites W1971290576 @default.
• W2593607777 cites W1980842253 @default.
• W2593607777 cites W1984099131 @default.
• W2593607777 cites W1991531197 @default.
• W2593607777 cites W2001260991 @default.
• W2593607777 cites W2007625270 @default.
• W2593607777 cites W2015293263 @default.
• W2593607777 cites W2016686931 @default.
• W2593607777 cites W2020705112 @default.
• W2593607777 cites W2021564164 @default.
• W2593607777 cites W2023559429 @default.
• W2593607777 cites W2028773329 @default.
• W2593607777 cites W2044491218 @default.
• W2593607777 cites W2051221402 @default.
• W2593607777 cites W2052686426 @default.
• W2593607777 cites W2052744592 @default.
• W2593607777 cites W2054058836 @default.
• W2593607777 cites W2055782613 @default.
• W2593607777 cites W2057291641 @default.
• W2593607777 cites W2058031442 @default.
• W2593607777 cites W2065335146 @default.
• W2593607777 cites W2065886456 @default.
• W2593607777 cites W2066146846 @default.
• W2593607777 cites W2068602562 @default.
• W2593607777 cites W2079211889 @default.
• W2593607777 cites W2083336183 @default.
• W2593607777 cites W2088425099 @default.
• W2593607777 cites W2096626388 @default.
• W2593607777 cites W2101934167 @default.
• W2593607777 cites W2115896474 @default.
• W2593607777 cites W2119176639 @default.
• W2593607777 cites W2121936687 @default.
• W2593607777 cites W2122337510 @default.
• W2593607777 cites W2126118567 @default.
• W2593607777 cites W2127162389 @default.
• W2593607777 cites W2141367941 @default.
• W2593607777 cites W2164440923 @default.
• W2593607777 cites W2171832928 @default.
• W2593607777 cites W2237164154 @default.
• W2593607777 cites W2329493760 @default.
• W2593607777 doi "https://doi.org/10.1021/acs.langmuir.6b03688" @default.
• W2593607777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28267920" @default.
• W2593607777 hasPublicationYear "2017" @default.
• W2593607777 type Work @default.
• W2593607777 sameAs 2593607777 @default.
• W2593607777 citedByCount "7" @default.
• W2593607777 countsByYear W25936077772017 @default.
• W2593607777 countsByYear W25936077772020 @default.
• W2593607777 countsByYear W25936077772021 @default.
• W2593607777 countsByYear W25936077772022 @default.
• W2593607777 countsByYear W25936077772023 @default.
• W2593607777 crossrefType "journal-article" @default.
• W2593607777 hasAuthorship W2593607777A5031163364 @default.
• W2593607777 hasAuthorship W2593607777A5040700979 @default.
• W2593607777 hasAuthorship W2593607777A5046541656 @default.
• W2593607777 hasConcept C113196181 @default.
• W2593607777 hasConcept C121332964 @default.
• W2593607777 hasConcept C125501631 @default.
• W2593607777 hasConcept C12554922 @default.
• W2593607777 hasConcept C130316041 @default.
• W2593607777 hasConcept C178790620 @default.
• W2593607777 hasConcept C185592680 @default.
• W2593607777 hasConcept C188324986 @default.
• W2593607777 hasConcept C192157962 @default.
• W2593607777 hasConcept C2778086801 @default.
• W2593607777 hasConcept C2779380641 @default.
• W2593607777 hasConcept C2779650302 @default.
• W2593607777 hasConcept C39944091 @default.
• W2593607777 hasConcept C41625074 @default.
• W2593607777 hasConcept C43617362 @default.
• W2593607777 hasConcept C44280652 @default.
• W2593607777 hasConcept C55493867 @default.
• W2593607777 hasConcept C62520636 @default.
• W2593607777 hasConcept C76564549 @default.
• W2593607777 hasConcept C8010536 @default.
• W2593607777 hasConcept C86803240 @default.
• W2593607777 hasConcept C91881484 @default.
• W2593607777 hasConceptScore W2593607777C113196181 @default.
• W2593607777 hasConceptScore W2593607777C121332964 @default.
• W2593607777 hasConceptScore W2593607777C125501631 @default.
• W2593607777 hasConceptScore W2593607777C12554922 @default.
• W2593607777 hasConceptScore W2593607777C130316041 @default.
• W2593607777 hasConceptScore W2593607777C178790620 @default.
• W2593607777 hasConceptScore W2593607777C185592680 @default.
• W2593607777 hasConceptScore W2593607777C188324986 @default.
• W2593607777 hasConceptScore W2593607777C192157962 @default.

• next