FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2593640400> ?p ?o ?g. }

• W2593640400 endingPage "e000591" @default.
• W2593640400 startingPage "e000591" @default.
• W2593640400 abstract "Background The effects of antihypertensive drug combination therapy on central blood pressure (BP) and augmentation index (AI) have not been fully elucidated. We investigated the effects of the direct renin inhibitor, aliskiren, or a diuretic added to an angiotensin II receptor blocker on AI in patients with essential hypertension. Methods A 24-week, prospective, multicentre, randomised, open-label study enrolled 103 patients already treated with valsartan. Participants were randomly allocated to receive either valsartan with aliskiren (V+A), or valsartan with trichlormethiazide (V+T). The primary outcome was the change in AI derived from radial artery tonometry. Secondary outcome measures included systolic and diastolic BP, cardio-ankle vascular index (CAVI, which reflects arterial stiffness) and urinary 8-hydroxydeoxyguanosine concentration. Results After 24 weeks, systolic and diastolic BP were significantly reduced in both groups to a broadly comparable extent. There was no significant difference in AI at the end of the study between the V+A group and the V+T group (between-group difference: −2.3%, 95% CI −6.9% to 2.2%, p=0.31). Central BP at the end of the study also did not differ between the two groups (p=0.62). There was no significant difference in the CAVI between the groups at the end of the study. Urinary 8-hydroxydeoxyguanosine concentration was significantly lower in the V+A group than in the V+T group (p Conclusion The combination of valsartan and aliskiren had an effect on AI comparable with that of the combination of valsartan and trichlormethiazide. UMIN Clinical Trial Registration number UMI05726." @default.
• W2593640400 created "2017-03-16" @default.
• W2593640400 creator A5000042144 @default.
• W2593640400 creator A5005116973 @default.
• W2593640400 creator A5011680174 @default.
• W2593640400 creator A5018338825 @default.
• W2593640400 creator A5036259503 @default.
• W2593640400 creator A5038761025 @default.
• W2593640400 creator A5044544721 @default.
• W2593640400 creator A5051726012 @default.
• W2593640400 creator A5059830493 @default.
• W2593640400 creator A5060520190 @default.
• W2593640400 creator A5076980836 @default.
• W2593640400 date "2017-03-01" @default.
• W2593640400 modified "2023-09-23" @default.
• W2593640400 title "Comparable effect of aliskiren or a diuretic added on an angiotensin II receptor blocker on augmentation index in hypertension: a multicentre, prospective, randomised study" @default.
• W2593640400 cites W1482820024 @default.
• W2593640400 cites W1984542647 @default.
• W2593640400 cites W1985023991 @default.
• W2593640400 cites W1997029586 @default.
• W2593640400 cites W1999636472 @default.
• W2593640400 cites W2002982077 @default.
• W2593640400 cites W2015264187 @default.
• W2593640400 cites W2018046263 @default.
• W2593640400 cites W2040179316 @default.
• W2593640400 cites W2045198428 @default.
• W2593640400 cites W2065057052 @default.
• W2593640400 cites W2077250787 @default.
• W2593640400 cites W2083844058 @default.
• W2593640400 cites W2084017921 @default.
• W2593640400 cites W2086334936 @default.
• W2593640400 cites W2121754021 @default.
• W2593640400 cites W2128206934 @default.
• W2593640400 cites W2147279241 @default.
• W2593640400 cites W2148183789 @default.
• W2593640400 cites W2168072390 @default.
• W2593640400 cites W2169709060 @default.
• W2593640400 cites W2252435576 @default.
• W2593640400 cites W2398579909 @default.
• W2593640400 cites W2985374558 @default.
• W2593640400 doi "https://doi.org/10.1136/openhrt-2017-000591" @default.
• W2593640400 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5384463" @default.
• W2593640400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28409014" @default.
• W2593640400 hasPublicationYear "2017" @default.
• W2593640400 type Work @default.
• W2593640400 sameAs 2593640400 @default.
• W2593640400 citedByCount "7" @default.
• W2593640400 countsByYear W25936404002020 @default.
• W2593640400 countsByYear W25936404002021 @default.
• W2593640400 countsByYear W25936404002022 @default.
• W2593640400 crossrefType "journal-article" @default.
• W2593640400 hasAuthorship W2593640400A5000042144 @default.
• W2593640400 hasAuthorship W2593640400A5005116973 @default.
• W2593640400 hasAuthorship W2593640400A5011680174 @default.
• W2593640400 hasAuthorship W2593640400A5018338825 @default.
• W2593640400 hasAuthorship W2593640400A5036259503 @default.
• W2593640400 hasAuthorship W2593640400A5038761025 @default.
• W2593640400 hasAuthorship W2593640400A5044544721 @default.
• W2593640400 hasAuthorship W2593640400A5051726012 @default.
• W2593640400 hasAuthorship W2593640400A5059830493 @default.
• W2593640400 hasAuthorship W2593640400A5060520190 @default.
• W2593640400 hasAuthorship W2593640400A5076980836 @default.
• W2593640400 hasBestOaLocation W25936404001 @default.
• W2593640400 hasConcept C104849204 @default.
• W2593640400 hasConcept C126322002 @default.
• W2593640400 hasConcept C126894567 @default.
• W2593640400 hasConcept C164705383 @default.
• W2593640400 hasConcept C198710026 @default.
• W2593640400 hasConcept C2777387769 @default.
• W2593640400 hasConcept C2779838083 @default.
• W2593640400 hasConcept C2779918671 @default.
• W2593640400 hasConcept C71924100 @default.
• W2593640400 hasConcept C84393581 @default.
• W2593640400 hasConcept C98274493 @default.
• W2593640400 hasConceptScore W2593640400C104849204 @default.
• W2593640400 hasConceptScore W2593640400C126322002 @default.
• W2593640400 hasConceptScore W2593640400C126894567 @default.
• W2593640400 hasConceptScore W2593640400C164705383 @default.
• W2593640400 hasConceptScore W2593640400C198710026 @default.
• W2593640400 hasConceptScore W2593640400C2777387769 @default.
• W2593640400 hasConceptScore W2593640400C2779838083 @default.
• W2593640400 hasConceptScore W2593640400C2779918671 @default.
• W2593640400 hasConceptScore W2593640400C71924100 @default.
• W2593640400 hasConceptScore W2593640400C84393581 @default.
• W2593640400 hasConceptScore W2593640400C98274493 @default.
• W2593640400 hasIssue "1" @default.
• W2593640400 hasLocation W25936404001 @default.
• W2593640400 hasLocation W25936404002 @default.
• W2593640400 hasLocation W25936404003 @default.
• W2593640400 hasOpenAccess W2593640400 @default.
• W2593640400 hasPrimaryLocation W25936404001 @default.
• W2593640400 hasRelatedWork W1977158051 @default.
• W2593640400 hasRelatedWork W1979276282 @default.
• W2593640400 hasRelatedWork W1996163108 @default.
• W2593640400 hasRelatedWork W2035765942 @default.
• W2593640400 hasRelatedWork W2074101390 @default.
• W2593640400 hasRelatedWork W2078998125 @default.
• W2593640400 hasRelatedWork W2110208984 @default.

• next