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- W2593669765 abstract "Therapy with systemic immunosuppressive drugs and biologics are the most potent therapies available to treat scleritis and are used in a number of clinical scenarios. The most frequent indication to use systemic immunosuppressive drugs is a corticosteroid-sparing therapy to allow the systemic corticosteroid dose to be reduced to a safe maintenance dose. Systemic immunosuppressive therapy is also used in combination with oral corticosteroids to treat associated systemic disease, most commonly severe vasculitis such as ANCA-associated vasculitis or vasculitic rheumatoid arthritis. In this chapter, the commonly used immunosuppressives in scleritis (the antimetabolites, azathioprine, methotrexate, mycophenolate mofetil; the T-cell inhibitors, cyclosporine, tacrolimus; and the alkylating agents, cyclophosphamide, chlorambucil) and biologic agents (TNF-α inhibitors, etanercept, infliximab, adalimumab; the IL-1 receptor antagonist, anakinra; the IL-2 receptor antagonist, daclizumab; and the anti-CD20/B-cell antibody, rituximab) will be discussed." @default.
- W2593669765 created "2017-03-16" @default.
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- W2593669765 date "2017-01-01" @default.
- W2593669765 modified "2023-09-27" @default.
- W2593669765 title "Management of Scleritis with Immunosuppressive Drugs and Biologic Agents" @default.
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- W2593669765 doi "https://doi.org/10.1007/978-3-319-49915-4_9" @default.
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