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- W2593670885 abstract "Due to an editing error, there was some misinformation relayed in the Abstract of the article by Kilpadi et al., Primary human marrow stromal cells and Saos-2 osteosarcoma cells use different mechanisms to adhere to hydroxylapatite, which was published in Volume 68A, Issue 2, pages 273–285, of the journal. The publisher apologizes for this error and offers, in its entirety, the corrected abstract, presented below. Abstract: One important step in bone formation on hard tissue implants is adhesion of osteoblast precursors to the implant surface. In this study, we used function-blocking antibodies against integrin subunits to characterize the mechanisms used by human marrow stromal cells and Saos-2 osteosarcoma cells to adhere to protein-coated hydroxylapatite (HA). We found that Saos-2 use both α5- and αv-containing integrins, whereas stromal cells use αv-containing integrins but not α5-containing integrins, despite the presence of α5-containing integrins on cell surfaces. On the basis of this difference, we examined binding of these cell types to HA coated with fibronectin (FN) or vitronectin (VN), to determine whether these ligands for α5 and αv integrins could enhance the numbers or morphology of cells adhered to them. We also examined the adhesion of cells to HA coated with RGD peptides designed to bind to FN or VN receptors. Morphology and number of adherent stromal cells were markedly enhanced on serum-coated surfaces compared with FN or VN alone, whereas, surprisingly, Saos-2 cells failed to spread on serum-coated HA and displayed superior spreading and stress fiber formation on FN-coated HA. Collectively, these results have important implications for the design of protein coatings to enhance the performance of HA implants. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 68A: 273–285, 2004 Key words: hydroxylapatite; fibronectin; vitronectin; integrins; osteoblasts" @default.
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- W2593670885 date "2005-03-09" @default.
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- W2593670885 title "Primary human marrow stromal cells and Saos-2 osteosarcoma cells use different mechanisms to adhere to hydroxylapatite" @default.
- W2593670885 doi "https://doi.org/10.1002/jbm.a.30290" @default.
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